Outcome Of Follwing Up 5 Years For First Episode Schizophrenia

Objective: To define the relationship between duration of untreated psychosis (DUP) and the time of appearing psychotic disorder and the evidence of the relationship between DUP and the prognosis of psychosis in five years. Methods: Using the recurrent research, it was selected that 32 cases of schizophrenia first diagnosed according to DSM-IV from January to March, 2005 in the Chonbuk national university hospital. The original data were collected by the Positive and Negative Syndrome Scale, Strauss-Carpenter Scale, Self-Report Insight Scale, Calgary Depression Scale for Schizophrenia. After getting the patients family' permission without invading the patients privacy, the followed research was carried on.Results: The results showed that (1) maintenance treatment, social-family supports, pre-morbid level of occupational function, apathy and onset patterns were the main determinants related to the global outcome at the end of five years' follow-up from discharge; (2) mean of DUP was 32. 10 + 34.49 weeks, and long DUP was correlated with to long-term hospitalization and duration of depressive disorder, statistically significant total CDSS and general psychopathology score of PANSS. Although not statistically significant, total and others each subscale scores of the PANSS of DUP>6 month group were higher than those of DUP<6 month group; (3) the action of suicide was affected by total work time, hospitalization, psychosis symptom, depression disorder and total function.Conclusion: (1) The results indicate that the factors play an important role in the five years' outcome of first episode schizophrenic patients. (2) This studysuggests that longer DUP can predict more poor outcome and course in first-episode schizophrenia. (3) DUP affects the action of suicide indirectly. (4) Insist of drug treatment can help improve symptom. Working can improve the -social function of relationship and work, study. (5) Early discover, early diagnosis, early treatments are still the most efficient pathway to improve the course, result and prognosis of schizophrenia...