Study In The Effects Of Acupuncture On Bone Histomophometry And Correlated Elements Concentrations Of SAMP6

Object: To study the effects of acupuncture on bone histomophometry and correlated elements concentrations of SAMP6. Methods: The femur of 3-month-old, 6-month-old SAMP6 and SAMR1; SAMP6 after acupuncture were processed undecalcified section for bone histomophometry, compared with SAMP6 without acupuncture and SAMR1. Correlated elements concentrations were assessed by means of atomic absorption spectroscopy in SAMP6, SAMR1 and SAMP6 after acupuncture. Results: 1. SAMP6 show early-onset and progressive osteoporosis, compared with SAMR1 in bone histomophometry. 2. There is a difference in correlated element level and distribution between SAMP6 and SAMR1. There are significantly decreased in Cu, Zn, Mg and Ca concentrations of femur; Cu and Mg concentrations of brain; Mg concentration of liver; Cu concentration of skin; Zn, Ca and Fe concentrations of blood serum in SAMP6 compared with SAMR1, while significantly increased in Zn and Mg concentrations of heart; Cu and Fe concentrations of lung; Cu concentrations of liver; Cu and Zn concentrations of kidney; Zn and Mg concentrations of skin; Cu and Mg concentrations of blood serum in SAMP6 compared with SAMR1. 3. After acupuncture "ZuSanli" point, there are significantly increased in Ca, Mg and Zn concentrations of the femur, and significantly decreased in Cu and Mg concentrations of serum in SAMP6. 4. Acupuncture on "ZuSanli" point can improve some bone histomophometry indexs to some degree. Conclusion: The results proved that SAMP6 were a novel osteoporosis animal model, which characteristics has no change since SAMP6 were introduced to China. It is successful breeding of SAMP6 in our hospital. It is possible that acupuncture has the function of regulating the level of correlated element in SAMP6 and acupuncture maybe have a good effect on senile osteoporosis in SAMP6.