| Cerebral stroke, as a common disease of the central nervous system (CNS), seriously harms people's health and claims high mortality rate and disability rate. Active rehabilitative therapy for its survivors can help 90% of them restore their ability to walk and take care of themselves, and 30% do some light work again. However, without active rehabilitative therapy, the rates in the two above recoveries can reach only 60% and 5% respectively. Therefore, the importance of rehabilitation of cerebral stroke survivors to improve their living quality and help them go back to the society has aroused increasingly great attention and so has the investigation into the mechanism of functional rehabilitation after CNS injury.Large amounts of experimentation and clinical research indicate that CNS of adult animals after CNS injury is plastic and recoverable, structurally and functionally, which makes it possible for them to rehabilitate after CNS injury. Cerebral plasticity refers to the ability of the brain to modify and adapt itself to the changed reality structurally and functionally. CNS plasticity is reflected onmany levels and in many taches, both on synaptic and neuron levels, pathway levels and on cerebral cortex level, which depends on the synchronic activation of many neurons necessary for any activity to be performed and the involvement of many nervous pathways and high central nerves. If the main region in charge of a given activity is injured or ailing, the activity in question will transfer to other neurons, nervous pathways and cerebral domains that regulate activities of the same kind. This change, on one hand, depends on the potential of the human nervous system, which can compensate and adapt to the anatomic and functional defects caused by an injury, such as secretion of various neurotrophic factors including BDNF, bFGF, etc. On the other hand, the change is closely related to how the patient exercises and learns before and after the injury in an acquired manner. In other words, if rehabilitative training (RT) can be performed in time, it can help the activity to transfer to a new pathway.RT is equally important in the early, middle and advanced phases of CNS injury. It is by interacting with other people and his or her environment that the patient trains and practices his or her prompt and appropriate reactions to outside stimulants to adapt to the new environment and pick up his or her skills and abilities to learn, live and work. It is a process. Unless the injury is extremely mild, the self-recovery of the CNS is invariably limited. Only by rehabilitative trainig of the functions and by exercise can the recovery and the ability of the patient to adapt to the environment and to live independently be improved. Nevertheless, the fundamental of all these, the mechanism involved, remains unanswered.The present study is a probe into this mechanism by means of observing the effects of RT on the expression of BDNF and bFGF in the in the cerebral cortexand hippocampus of cerebral infarcted rats in an attempt to contribute theoretically to the clinical rehabilitation therapy of cerebral stroke.Both BDNF and bFGF are important members of the neutrophic factor family and there has been a great deal of research on their impacts on nerve injuries in the past decade. Distributed in the CNS, they can strongly stimulate and promote the growth and differentiation of neurocytes, put off the degeneration and aging of neurons, maintain the survival and normal functions of neurocytes and promote the repair of injured cells.In the present experiment, 6 rats were randomly selected from 54 rats and were used as control. 48 were randomized into Id, 3d, 7d, and 14d groups as RT experimental groups and immobilized (IM) group 24h after the rat model of cerebral stroke had been immobilized, with 6 rats in each group. The model was prepared by photochemical induction method; cholorophyll derivative IV (CPD4) was used as photosensitizer; He-He laser was used to irradiate the domains in...
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