| Objective: To observe the stabilization effect of Chinese medicine prescription to coronary atherosclerosis plaque and explore its mechanism of effect. Methods: Seventy patients of coronary heart disease (CHD) with angina were divided randomly into treatment group (36 cases) and control group (34 cases).Conventional western medical therapy was given to both groups.At the same time, the treatment group recived the decoction to boost the kidney and fortify the spleen and to quicken the blood and transform the phlegm. And the control group recived Simvastatin.The changes of clinical symptoms and laboratory indexs in all the patients were observed before and after treatment. Results: In the treatment group, the total effective rate of meliorating symptoms and the remarkable rate were respectively 97.22% and 72.22%,which were significantly better than those of the control group ,P<0.05 or P<0.01. Meanwhile, the level of TC, TG, LDL-C, TXB2, ET-1, WBC, ESR, CRP, Fgwere decreased and the level of HDL-C, NO, PGI2, were increased remarkably after treatment,which were statistically different compared with those of the control group ,P<0.05 or P<0.01. Conclusion: The Chinese medicine with the therapeutic method of boosting the kidney and fortifing the spleen and quickening the blood and transforming the phlegm has the evident effect to stabilize the coronary atherosclerosis plaque. |
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