Clinical Study Of Qi-boosting Blood-quickening Detoxicating Effection On Coagulation Index In The Patients With Sepsis

Objective This clinical study,through the observation method of qi-boosting blood-quickening detoxicating therapy on sepsis with heat- toxin,gas-deficiency and blood-stasis type by clinical study, we observed its influence on the acute physiology and chronic health evaluation Ⅱ(APACHE-Ⅱ score),sepsis related organ failure assessment(SOFA score),tumor necrosis faetor-a(TNF-α), hypersensitive C reactive protein(hs-CRP), platele(PLT), aetivated partial thromboplastin time( APTT), prothrombin time(PT), Ddimer(D-Di), antithrombin III(ATIII), activated Protein C(APC) levels of change and influence.From the aspects of clinical symptoms,sings and laboratory indexes and conventional western medicine treatment group comparison analysis,we verify the efficacy of method of q i-boosting blood-quickening detoxicating treatment on patients with sepsis,and the influence on patients with coagulation disorder.We want to explore the possible mechanisms of qi- Boosting blood-quickening detoxicating therapy so it can provide objective basis for traditional C hinese and western medicine treatment of sepsis with coagulation disorder,and offer new ideas and methnods.MethodsWe choose 60 patients diagnosed as sepsis with heat-toxin,gas-deficiency and bloodstasis type in IC U in our hospital from January 2014 to December 2014, they were randomly divided into two groups, control group of 30 patients, the treatment group of 30 patients. The control group received conventional western medicine treatment(antibiotics, stabilizing internal environment, nutritional support, inspiring oxygen, using ventilator when patients need assisting with breathing, fluid resuscitationdiuretics, stabilizing circulation and treatment of the primary disease, etc.). The treatment group received qi-boosting blood-quickening detoxicating therapy(Shen Mai injection + Sodium Tanshinon Ⅱ Asilate injection+reduqing aral likuid) on the basis of conventional western medicine treatment,taking 7 days as one course of treatment. Before and after seven days treatment, Patients were observed about changes of APACHE-Ⅱ score, SOFA score,TNF- α,CRP,PLT,APTT,PT,Fbg,D-dimer,ATIII,APC,and comparing clinical prognosis of the two groups.Results 1. The level of APAC HE-Ⅱ score and SOFA score in the treatment group decreased significantly after treatment, compared with the control group was statistically significant(P <0.05).2. In terms of Inflammatory response indicators, The level of TNF-α and hs-CRP in the treatment group decreased significantly after treatment, compared with the control group was statistically significant(P <0.05). 3. The level of coagulation related indicator(PLT 、 APTT 、 PT、 D-dimer) in the treatment group improved significant,compared with the control group was statistically significant(P <0.05). 4.The level of anticoagulation related indicator(AT-III、APC) in the treatment group improved significant,compared with the control group was statistically significant(P <0.05). 5. In terms of prognostic outcome, the dath rate of treatment group(13.4%) is better significantly better than the control group(26.7%), but the two groups have no significant difference(P >0.05).Conclusion Qi-boosting blood-quickening detoxicating therapy on sepsis has obvious clinical effect, can reduce APACHE-Ⅱ score and SOFA score, correct the disorder of coagulation function. Q i-boosting blood-quickening detoxicating therapy achieved the purpose of treating disease and improving the patient’s prognosis and outcome maybe through inhibiting excessive inflammatory response, improving coagulation index, strengthening the anticoagulant function and improving microcirculation. This study, no obvious adverse drug reactions, provides objective indicators for integrative medicine treatment of sepsis with coagulation disorder and reflects the the characteristic of Chinese medicine.