Studies On Serum Adiponectin Levels In Patients With Type 2 Diabetes And It's Relation To Insulin Resistance

Objective: To study the relationship between serum adiponectin levels and insulin resistance in type 2 diabetic patients with coronary heart disease.Methods: 34 type 2 diabetic patients and 35 patients with coronary heart disease and 30 type 2 diabetic patients with coronary heart disease and 30 health people were investigated. The serum adiponectin level was assayed by RIA. Meanwhile, TG and FINS and BMI were measured and HOMA-IR index werecalculated.Results: The levels of serum adiponectin both in type 2 diabetic group and in CHD group were lower than that in control. The level of serum adiponectin in the group which both have type 2 diabetes and CHD was lower than that in type 2 diabetic group (10.90 ±0.33 VS 28. 78±0. 76 p<0.01); While, the HOMA-IR index was lower in the group which both have type 2 diabetes and CUD than that in the type 2 diabetic group (0.99 ±0.55 VS 1.34±0. 75 p<0. 05) ; The level of serum adiponectin in the group of type 2 diabetes showed negative correlation with BMI and significantly negative correlation with HOMA-IR index. Using the method of multiple linear regression, it showed that the level of serum adiponectin only related with HOMA-IR.Conclusion: The levels of serum adiponectin both in type 2 diabetic group and in CHD group were significantly decreased. The level of serum adiponectin in the group of type 2 diabetes with CHD is the lowest among the three groups. It is negatively related to HOMA-IR. This shows that the level of serum adiponectin was related to insulin resistance and macrovasculardisease in type 2 diabetic patients.