| Nowdays,type 2 diabetes is one of the diseases which are influencing people's lives and healths seriously. Macroangiopathy is the important factor which result in disability and death of the patients with type 2 diabetes.The risk of occurring angiocardiopathy event in the patients with type 2 diabetes rises 3-4 times over that in the patients without type 2 diabetes. The DM patients'macroangiopathy is threatening their survival and quality of life . Therefore, approaching the nosogenesis of the T2DM patients'angiocardiopathy is very significant to prevent or delay its occurrence and development.Adipose tissue is currently considered as a hormonally active system in the control of metabolism and not only as a store of excess energy. It's found that adipocytes produce and secrete a variety of biologically active molecules,conceptualized as adipocytokines. Adiponectin is a recently discovered adipocytokine which is specifically expressed in white adipose tissue,high sensitive C-reactive protein is a kind of inflammation marker。Many studies show that adiponectin is found to be decreased in patients with obesity, type 2 diabetes, cardiovascular disease, and high sensitive C-reactive protein is found to be increased. Adiponectin and CRP may participate the occurrence and pathogenesis of diabetes with coronary artery disease.Objective : To assay the serum APN, Hs-CRP levels in normal subjects and the patients with type 2 diabetes mellitus(T2DM) ,and to explore the correlation between them and coronary artery disease and offer a new clinical therapeutic thread for diabetes with coronary artery disease.Method:Thirty cases of type 2 diabetic patients ,Thirty cases of type 2 diabetic patients with stable angina pectoris(DM￡SAP),thirty cases oftype 2 diabetic patients with acute coronary syndrome(DM￡ACS)and thirty cases of healthy control subjects(CONTROL group) entered the study.All subjects have not any personal history of diabetes, blood sample were obtained after a 8-10h overnight fast, plasma fasting glucose, glycosylated hemoglobin(HbA1c),TC,TG,HDL-C,LDL-C , height and weight were measured by standard laboratory techniques.Levels of APN were measured by enzyme-linked immunosorbant assay(ELISA)and levels of Hs-CRP were measured by scatter velocity turbidimethy. All subjects of DM￡ACS and ten subjects of DM￡SAP underwent coronary angiography.Results:1. The fast plasma glucose concentrations, HbA1c concentrations and BMI in three groups were significantly higher than those in controls(P﹤0.05).The TC,TG and LDL-C concentrations in SAP and ACS groups were higher and HDL-C lower than compared with control subjects (P﹤0.05). There were no statistical differences for BMI, FPD, blood lipid concentrations, HbA1c concentrations in SAP group,ACS group and pure DM group(P>0.05).2. The serum CRP concentrations were higher in diabetic subjects than in controls(P<0.05).The serum CRP concentrations were higher in SAP group than in pure DM group(P<0.05). The serum CRP concentrations were higher in ACS group than in SAP group(P<0.05). The serum adiponectin concentrations were lower in diabetic subjects than in controls(P<0.05). The serum adiponectin concentrations were lower in SAP group than in pure DM group(P<0.05). The serum adiponectin concentrations were lower in ACS group than in SAP group(P<0.05).3. The inverse correlation among serum adiponectin and CRP remained significant (partial r=-0.553, P<0.01)Conclusions:1,We observed hypoadiponectinemia in diabetes with coronary heart disease patients ,especially in ACS group. Adiponectin reflects the stability of coronary artery stenosis which may predicts the occurrence and development of coronary artery disease.2,Low levels of serum adiponectin are associated with higher levels of hs-CRP . The level of adiponectin has the predictive value in thegeneration of atherosclerosis, and may be useful in evaluating prognosis of coronary artery disease. |
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