Study On Antistatic And Antidepressant Effects

The anxiolytic and antidepressant effects of TS were investigated by means of behavioral pharmacology for the first time. The other central-acting properties of TS were also examined to see whether clear differences could be observed between it and diazepam (DZ).In the marble-burying test, TS (4,16 mg/kg, ig) decreased the burying number of marbles. In the elevated plus-maze test, TS (4 mg/kg, ig) increased the percentage of open arm entries and the percentage of open arm time.TS (64 mg/kg, ig) prolonged the time spent in light area and reduced the latency entered the light box without altering the total locomotor activity of the animals in the light/dark box. In the hole-board test, TS (1,4 mg/kg, ig) caused increase in exploratory head-dipping time in mice and decreased the head-dipping latency significantly. In the open field test,TS (16 mg/kg, ig) significantly increased the number of entries into the central area and the time spent in central area, TS (4,16 mg/kg, ig) demonstrated the antithgmotactic effect. TS (16 mg/kg, ig) significantly increased the food intake in a 5-minute period in the mouse novel food consumption test.TS(1,4mg/kg,ig)significantly inhibited stress-induced hyperthermia. In foot-shock induced aggression behavior test, TS (16,64 mg/kg, ig) significantly increased the inhibition ratio of fighting time in mice. In general, the results seen above indicate that TS, at specific doses, possesses a wide range of anxiolytic properties in different anxiety models.TS (64 mg/kg, ig) produced a reduction in immobility time in the tail suspension test. TS (16,64 mg/kg, ig) reduced the duration of immobility in the forced swimming test.At doses eliciting the anxiolytic and antidepressant effects, TS produce neither influence on amobarbital sodium-induced sleeping, nor disrupting learning and memory. The results of the traction test and the inclined plane test showed that TS did not impair muscle tone. These results suggest that TS has no diazepam-like side-effects, such as over-sedation, amnesia, muscle relaxation and amobarbital potentiation.In conclusion, these findings indicate that TS exhibits an anxiolytic-like and antidepressant effects at given dosage.