The Value Of 3.0T Magnetic Resonance Imaging Imaging In Evaluating The Short - Term Curative Effect Of Radiotherapy And Chemotherapy For Cervical Cancer

Objective: To study the imaging methods for evaluating the response to chemoradiotherapy in uterus cervical cancer, and to discuss the MDCE-MRI and DWIvalue of the early assessment and prediction in recent curative effets of UCC, consequently finding the best evaluating parameter to provide a kind of imaging technology for evaluating the tumor therapetic response.Methods: 52 cases of cervical cancer patients confirmed by pathology in our hospital in January 2012-2014 period November to prepare chemotherapy, before the group were not related to cancer treatment done. For all enrolled patients with cervical cancer, respectively,before and after treatment began 15 days, one month, two months with a 3.0T GE Signa HDx scanner for routine MR scan and DWI examination, of which 21 patients were also conducted MDCE-MRI scan. Semi-quantitative measurement of the corresponding parameter values ??for different points of time by checking ADW 4.3 workstation,including the apparent diffusion coefficient(ADC) values, the time- signal intensity curve(Time-signal Intensity curve, TIC), the average time to strengthen(Mean time to enhancement, MET), peak time(Time to peak, TTP), the largest increase in slope(Maximum slope of increase, MSI), the largest decline in slope(Maximum slope of decrease,MSD), negative integral(Negative enhancement integral, NEI). According to the maximum diameter of the tumor after treatment, the patients were divided into changes in complete remission and partial remission. Analysis of the differences between the two groups before treatment and after treatment difference parameter parameter changes, and after cancer treatment rate of change of each parameter value line ROC curve analysis, simultaneous analysis parameters worth two groups after chemotherapy and tumor shrinkage rate of change of the rate of correlationResult: ADC values ??change earlier than the morphological changes in tumor volume after treatment was significantly higher than the ADC value before treatment, EADC lower than before; the first 15 days of treatment compared with before treatment, the mean ADC values ??increased after the start(t = 11.119, P <0.05), EADC value decreased(t =-9.916,P <0.05), tumor The maximum diameter before treatment compared with no significant change(t =-1.797, P> 0.05);after two months of treatment tumor size reduction rate ADC values ??before treatment negatively correlated(r =-0.658, P <0.05); By ROC curve analysis, taking maximum points Youden index as a diagnostic point that the ADC value of0.891 × 10-3mm2/ s. By non-linear regression analysis to yield the formula y =(1525500.122x2-4689.962 x + 3.482) × 100%, ADC value use prior to treatment, treatment may be calculated after complete remission percentage. Before treatment MSI, NEI partial remission large group, the difference was statistically significant. 15 days of treatment ishigher than the growth rate of complete remission NEI partial remission group, there are two significant differences between comparison, P <0.05. After one month of treatment complete remission TTP, NEI growth rate is higher than the partial remission group, the parameters were significantly different between the two groups, P <0.05. Analysis the area under the ROC curve of the rate of change,in tumor ADC and NEI ROC curves, the maximum rate of change of ADC, the highest diagnostic performance. Correlation analysis of the parameters before and after treatment showed that ADC values, therapy TTP value and rate of change NEI values ??were positively correlated with cervical cancer.Conclusions : Parameter values MDCE-MRI and DWI evaluation and prediction of cancer chemotherapy and radiation therapy has some clinical value, ADC value is more sensitive to cancer chemotherapy and early response.