Evaluation Of The Efficacy Of SS-QOL And SAQ In The Treatment Of Heart And Brain Disease (phlegm And Blood Stasis Syndrome)

Purpose：Through Seattle angina questionnaire (SAQ) and stroke thespecialized quality of life scale (SS-QOL) to evaluate the curativeefficiencies of "HexueTongma" Particles for patients withCardio-cerebral joint Disease(With Phlegm and Blood Stasis Mutual),anddoing the trend diagram to analyse efficacy.Material and method：Basedon the core periodical literature researchanalysis, the preliminary works such as archives of internal medicine oftraditional Chinese medicine research, reference standards, norms,industry authority through expert repeated proof, formulatecardio-cerebral disease differentiation rule research questionnaire.Using randomized, double-blind, controlled, multicenter clinical trialdesign method of selecting more than7second grade a hospitals in Liaoningprovince clinical trial data collection. Seven branch respectively:Liaoning university hospital of traditional Chinese medicine, secondaffiliated hospital of Liaoning university of TCM, thrombosis in Liaoningprovince, Chinese medicine hospital in Yingkou,Chinese medicine hospitalin Dandong, Chinese medicine hospital in Fuxin, Chinese medicine hospitalin Shenyang. In patients with to explain research purpose and content,sign a written informed consent, in strict accordance with the diagnosticcriteria, inclusion criteria and exclusion criteria, excluding standardscreening cases. Using SAS statistical software, according to the casesof units allotment and random proportion form grouping random number table,according to the random digit grouping method, the subjects were randomlyallocated to treatment group or control group, by this method in383patients for clinical trials, the treatment group191cases, control group 192cases. Based on unclogged arteries and blood particles combinedwestern medicine therapy interventions as treatment group, placebocombined western medicine foundation treatment intervention as controlgroup, treatment for8weeks, followed up for1year. By data managementanalysis,5patients were lost to follow-up, super time window and knockedout, but the complete treatment period in all5cases, so as the researchobject of this study is to include all patients. Data acquisition throughmultiple visit to view collection, relevant information including generaldata, safety data and curative effect evaluation index (Seattle anginaquestionnaire and TCM symptom of cerebral apoplexy specialized qualityof life scale), etc. Based on383cases of patients with clinicalinformation, group t test, rank and inspection, chi-square statisticanalysis methods, such as, from Seattle angina questionnaire (SAQ) andstroke the specialized quality of life scale (SS-QOL) two aspectsanalysis "HexueTongma" Particles for patients with Cardio-cerebral jointDisease(With Phlegm and Blood Stasis Mutual), and make a trend chart,signing "HexueTongma" Particles superiority than foundation of westernmedicine therapy, in order to guide clinical drug use.Results：1Seattle angina questionnaire (SAQ) center colic stable state ofimprovement, the treatment group was better than control group (P <0.05),trend analysis, according to the state of stable angina in application"HexueTongma" Particles month that has a good effect.2Stroke specialized quality of life scale (SS-QOL), the treatment groupin spiritual vigor, activity ability, social communication, thinkingability, upper limb function, job skills, and so on six dimensions ofcurative effect is better than that of control group (P <0.05); Trendanalysis shows. With the continuation of treatment time, mental vigor, activity ability, thinking ability, upper limb function, the ability towork is getting better in five dimensions, such as state, socialcommunication has no obvious relation with the continuation of treatmenttime.3During the trial, not present with the test drug related adversereactions, adverse events, etc.Conclusion："HexueTongma" Particles treating Cardio-cerebral joint Disease(WithPhlegm and Blood Stasis Mutual) effect is obvious and safety, mainlyreflected in caused by cerebrovascular disease state of stable anginapectoris and improve function of limbs movement.