| ObjectiveThrough cl inical research, the use of Yiqi Huatan Quyu Tongluo Prescript ion and Yiqi Huatan Quyu Prescription in treatment of COPD, observation of Yiqi Huatan Quyu Tongluo Prescription on clinical efficacy in patients with stable COPD.MethodSelect the standard diagnosis of Western medicine and TCM syndrome type of COPD belongs to the lung spleen and kidney deficiency, phlegm and blood stasis, and patients who meet the inclusion criteria. The patients were randomly divided into 50 cases, Xiaozheng Tongluo group 25 cases, control group 25 cases. The two groups were given conventional treatment of Western medicine, Xiaozheng Tongluo group was treated with Yiqi Huatan Quyu Tongluo Prescription, the control group at the same time given Yiqi Huatan Quyu Prescription, treatment for 8 weeks, fol lowed up regularly. Records into groups of patients before treatment and after treatment of general information, security index (blood routine,liver function, kidney function), therapeutic effect index (the main symptom integral, integral of TCM syndrome, pulmonary function, ultrasound, CAT, MMRC,6MWT Beckoning), statistical analysis.Results1.General information:A total of 50 cases of the patients, randomly divided into Xiaozheng Tongluo group 25 cases, control group 25 cases, removal of group of 7 cases,1 cases with acute exacerbation of exit,6 cases fall due to poor compliance, eventually incorporated into the statistical analysis of the number of cases in 43 cases. Male 32, female 11; mean age 69.07+9.74 years old, the youngest was 51 years old, the oldest was 87 years; mean duration of disease was 2.59+1.65 years, the shortest duration is 1 years, the longest duration of 6 years.2.The influence on pulmonary function:FEV1 accounted for the expected value percentage were significantly improved (P<0.05), compared to two groups (P< 0.05), Xiaozheng Tongluo group accounted for the percentage of predicted value superior to control group in improving the FEV1; and the improvement in FEV1/FVC% two groups no effect (P>0.05).3.The influence on the major symptoms:The major symptoms before and after treatment in the two groups of integral were significantly improved (P<0.05), the statistical analysis between the two groups, the results showed that there was no significant difference between the two groups (P>0.05).4. The influence on Syndrome of traditional Chinese Medicine:Before and after treatment in the two groups of lung qi deficiency, spleen qi deficiency, kidney deficiency, blood stasis, phlegm integral were significantly improved (P<0.05), inter group comparison of lung qi deficiency, kidney deficiency, phlegm integral no significant difference between two groups (P>0.05), spleen qi deficiency syndrome integral improvement than the control group Xiao zheng Tong luo group (P<0.05), blood stasis score improved Xiao zheng Tong luo group than in the control group (P<0.05); the two groups before and after treatment of kidney deficiency, phlegm obstruction to improve the effective rate had no difference (P>0.05), Qi deficiency and blood stasis, improve the efficiency of Xiaozheng Tongluo group than in the control group (P<0.05) the spleen qi deficiency syndrome, improve the efficiency of Xiao zheng Tong luo group than the control group (P<0.05).5. The influence on CAT:Before and after treatment in the two groups of CAT scale scores were significantly improved (P<0.05), the results showed no significant difference between the two groups (P>0.05).6. The influence on mMRC:Before and after treatment in the two groups of mMRC scale scores were significantly improved (P<0.05), the results showed no significant difference between the two groups (P>0.05).7. The influence on 6MWT:Before and after treatment in two groups were not significantly different between the 6MWT (P>0.05), no significant difference between the two groups (P>0.05).8. The influence on pulmonary artery pressure:The two groups before and after treatment of pulmonary arterial pressure increased significantly (P<0.05), no significant difference between groups (P>0.05). 9. Safety:The patients in the medication process, not the skin pruritus, erythema, papules, wheal allergic reaction, also no other adverse reactions, the vital signs were stable. During the treatment, blood routine, liver function, renal function in patients of two groups were no significant change.The research conclusion1. Yiqi Huatan Quyu Tongluo Decoction can improve the pulmonary function of patients with COPD, the main symptoms, TCM syndrome, mMRC scale, CAT scale score in a certain extent, to improve lung function, lung qi deficiency syndrome, blood stasis syndrome of FEV15 is better than that of Yiqi Huatan Quyu recipe;Yiqi Huatan Quyu recipe in the improvement of spleen qi deficiency syndrome is better than that of Qi and phlegm removing blood stasis and dredging collaterals. stasis is superior to that of Yiqi Huatan Quyu Prescription.2.Yiqi Huatan Quyu Tongluo Prescription has good safety. |
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