| Objective:Discussion phlegm-dampness constitution of obstructive sleep apnea hypopnea syndrome (OSAHS) with hypertension (HT) and/or abnormal circadian rhythm of patients, nasal automatic continuous positive airway pressure (auto CPAP) treatment, on the blood pressure changes in the situation of the research.Materials and methods:Collect March 2014 to March 2015 in China Academy of Chinese Medical Sciences Guang’an Men Hospital ear nose and throat out-patient and Guangan door hospital south sleep clinic visits, by polysomnography (PSG) diagnosis of OSAHS and by the Chinese constitution classification criteria, in accordance with phlegm dampness constitution,24 hours dynamic state blood pressure (24hABP) examination conforms to the patients with abnormal circadian rhythm of HT and/or blood pressure, a total of 33 cases. Among them,30 cases of HT patients, including 9 cases of patients with HT, previous oral antihypertensive drug regimens remain unchanged; this study newly discovered 21 HT patients. No previous oral antihypertensive drugs, temporarily given oral medication. In 33 cases,21 cases of abnormal circadian rhythm of blood pressure (16 cases and 5 cases of superficial dipper type blood pressure anti dipper blood pressure). Given the auto CPAP patient per night and effective continuous treatment for 1 week (all selected patients are reached:moderate to severe OSAHS, respiratory disturbance index (AHI) is less than or equal to 10/hour; mild OSAHS AHI decreased is more than or equal to 50 percent), nightly sleep duration of treatment not less than 7 hours. After 1 weeks of treatment,24hABP was reviewed. Blood pressure significantly improved after treatment in patients with, in order to persistent effect to influence the blood pressure of the auto CPAP do further observation and discussion, in based on the principle of voluntary patients. In some patients with prolonged treatment time (a total of 33 patients,22 cases of prolonged duration of treatment up to 2 weeks,22 cases in the and 11 cases extended to 4 weeks). Data analysis using IBM SPSS statistics 19.0 statistical software for statistical analysis, mean+standard deviation for measurement data, therapeutic effect by t test and non parametric test is evaluated, between multi factors correlation analysis using partial correlation analysis, to P< 0.05 as the difference is statistically significant standard.Result:1. compared with 30 cases of phlegm dampness constitution OSAHS patients with HT by auto CPAP treatment 1 week after,24hABP each time blood pressure compared with those before treatment were significantly lower,24hSBP/DBP is reduced by an average of about 5.73/3.43mmHg, dSBP/DBP is reduced by an average of about 5.40/3.53mmHg, nSBP/DBP is reduced by an average of about 7.03/2.73mmHg. Among them, except nDBP, the blood pressure before and after treatment were statistically significant (P< 0.01).2.30 cases of phlegm dampness constitution OSAHS patients with HT in,9 cases of history of HT and maintain oral antihypertensive drugs and 21 cases of the newly discovered HT without antihypertensive drugs of two groups of patients compared to, after 1 week of treatment, changes to the nsbp, ndbp only have statistical significance (P<0.01), exports of service drugs in patients with nocturnal BP is more obvious, and 24hsbp,24hdbp, dsbp, ddbp changes no statistical significance (P> 0.05), did not show significant difference. The partial phlegm dampness constitution OSAHS with HT patients with prolonged treatment time, of which 21 cases of extended treatment time to 2 weeks,21 cases in which 11 cases of extended treatment time to 4 weeks. In the observation period for 1,2,4 weeks after depressurization amplitude compared, only for 1 week and 2 weeks dsbp change was statistically significant (P =0.044<0.05), more than 24hABP each time blood pressure changes were in the first week of treatment significantly, and no with the extension of treatment time and once again showed obvious and significant change (P> 0.05).3. after 1 week of treatment,21 cases of abnormal circadian rhythm of blood pressure, the original 16 cases of superficial dipper type blood pressure have 5 cases changed to normal dipper type blood pressure,8 cases of rhythm was not changed,3 cases of anti dipper blood pressure; original 5 cases of anti dipper blood pressure in 1 case variable dipper type blood pressure,4 cases become shallow dipper type blood pressure. Treatment after 1 week of 15 cases of circadian rhythm of blood pressure in patients with abnormal of 9 cases of treatment is prolonged to 2 weeks, including 2 cases of shallow dipper type blood pressure and 1 cases of anti dipper type blood pressure change as dipper type blood pressure, there are 6 patients did not change. Treatment after 2 weeks of 6 cases of shallow spoon shaped in 3 cases of the treatment time was prolonged to 4 weeks, which change 1 case dipper type blood pressure,2 cases is still shallow dipper type blood pressure.Conclusion:1. Auto-CPAP treatment of phlegm dampness constitution OSAHS helps to control and improve the blood pressure of patients..2. phlegm dampness constitution OSAHS with HT patients by atuo-CPAP treatment 1,2, and 4 weeks, the blood pressure decrease occurred mainly in the first week of treatment, so clinical recommendations to the 24hABP after the end of the first week of the auto CPAP treatment data as a reference, this for phlegm dampness constitution in OSAHS patients with HT a medication or adjustment has certain clinical significance.3. in the auto CPAP in phlegm dampness constitution OSAHS patients with HT treatment. This study showed that with a history of oral antihypertensive drugs than those without oral antihypertensive drugs in patients with nocturnal blood pressure (nsbp, ndbp) decreased substantially more.4. The study showed that with the extension of the treatment time, the circadian rhythm of blood pressure gradually improved with the extension of the treatment in 4 weeks..
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