| Object:To evaluate the curative efficacy of traditional Chinese medicine for precancerous lesions of gastric cancer (PLGC). To mine and summarize professor of zhen-hua li’s academic experiences on diagnosis and treatment of PLGC at the treatment of chronic atrophic gastritis to cancer academic experience.Method:Part1:Establish a Strict set of inclusive and exclusive criteria. Strict strategy of literature retrieval was also established. Randomized controlled trial of traditional Chinese medicine were identified form wan fang Resource database (-2014), CNKI database, VIP Chinese technique Magazine database, Biology Medical literature database (CBM), PubMed, Cochrane library, Embase. Evaluated and analyzed these datas according to the cochrane handbook.Part2:Sorted clinical datas of patients who were diagnosed with PLGC, and they were treated by professor zhen-hua 1i. Extracted 73 patients,134 clinical medical datas using TCM Inheritance assistant platform designed by China academy of traditional Chinese medicine. Data mining methods such as descriptive statistics, association rules, clustering analysis were useded to mine the distribution of TCM disease, distribution of syndrome, drug use frequency, the relationship of Chinese medicinal herb and syndrome and the relationship between Chinese medicinal herbs. Finally, summed up experiences of diagnosis and treatment of professor zhen-hua 1i.Result:Part1:1053 literature were retrieved,9 RCT were finally included invol ing 992 patients. Below are the results of meta-analysis:the curative effect of TCM vs western medicine showed:Test of heterogeneity:12=0%, P=0.46, no significant heterogeneity, using the fixed effect model, combined effect size RR=1.28, (95% CI [1.18,1.38]), P<0.0001, there is a significant difference statistically in term of between treatment group and control group, the effectiveness of TCM being higher than western medicine. Efficacy of gastroscope:Test of heterogeneity of three articles:12=0%, P=0.49, no signif icant heterogeneity, using the fixed effect model, combined effect size, RR= 1.24 (95% CI [1.05, 1.46]),P=0.010, there is a significant difference statistically in term of between treatment group and control group, the effectiveness of TCM being higher than western medicine. The pathological effect:Test of heterogeneity of three articles:12=0%, P=0.42, no significant heterogeneity, using the fixed effect model, combined effect size, RR= 1.26, (95% CI [1.06,1.50]), P=0.010, there is a significant difference statistically in term of between treatment group and control group, the effectiveness of TCM being higher than western medicine. Total curative effect of gastroscopy and pathological:Test of heterogeneity of two articles:12=0%, P=0.89, no significant heterogeneity, using the fixed effect model, combined effect size, RR= 2.04, (95% CI [1.43,2.91]), P< 0.0001, there is a significant difference statistically in term of between treatment group and control group, the effectiveness of TCM being higher than western medicine. Mucosal hyperemia:Test of heterogeneity of three articles:12=30%, P=0.25, no significant heterogeneity, using the fixed effect model, combined effect size, RR= 1.18, (95% CI [0.95,1.46]), P=0.14, there is no significant difference statistically in term of between treatment group and control group. Mucosal pale:Test of heterogeneity of two articles:12=0%, P=0.34, no significant heterogeneity, using the fixed effect model, combined effect size, RR= 1.48 (95% CI [1.04,2.11]), P=0.03, there is a significant difference statistically in term of between treatment group and control group, the effectiveness of TCM being higher than western medicine. Mucosal erosion:Test of heterogeneity of three articles:12=0%, P=0.58,no significant heterogeneity, using the fixed effect model, combined effect size, RR= 1.17 (95% CI [0.93, 1.47]), P=0.19, there is no significant difference statistically in term of between treatment group and control group. Mucous membrane hyperplasia of particles:Test of heterogeneity of three articles:12=0%, P=0.45, no significant heterogeneity, using the fixed effect model, combined effect size, RR= 1.20, (95% CI [0.77,1.85]), P=0.42, there is no significant difference statistically in term of between treatment group and control group. Mucosal blood vessels through see:Test of heterogeneity of two articles:12=11%, P=0.29, no significant heterogeneity, using the fixed effect model, combined effect size, RR= 1.44, (95% CI [0.96,2.18]), P=0.08, here is no significant difference statistically in term of between treatment group and control group. Bile reflux:Test of heterogeneity of three articles:12=0%, P=0.95 no significant heterogeneity, using the fixed effect model, combined effect size, RR= 1.59, (95% CI [1.19,2.11]), P=0.02, there is a significant difference statistically in term of between treatment group and control group, the effectiveness of TCM being higher than western medicine.Part2:73 patients and 134 clinical times were included in the study, disease of traditional Chinese medicine, respectively, distention and fullness (67 cases), epigastric pain (46 cases), gastric discomfor (11 cases), acid reflux disease (10 cases).10 kinds of syndrome types, followed by the syndrome of disharmony between 1 iver and stomach (45 cases), yin deficiency and qi stagnation syndrome (20 cases), spleen deficiency and dampness heat syndrome (18 cases), spleen stomach damp heat syndrome (16 cases), weakness of the spleen and stomach syndrome (14 cases), spleen deficiency and dampness heat syndrome (13 cases), type of qi stagnation and blood stasis (13 cases), liver stomach heat syndrome (11 cases), liver spleen Disharmony Syndrome (9 cases), yin deficiency and heat stagnation syndrome (3 cases), respectively. The main symptoms are:epigastric fullness, insomnia, stomach pain, eat less, chills, acid regurgitation, loose stool, epigastric burning, belching, irritability etc. The Chinese herbal medicine to cure PLGC of Professor Li Zhenhua commonly used are:bupleurum, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Poria, Radix Scutellariae, Radix Glycyrrhizae, cuttlebone, dried tangerine peel, Coptis, pinellia, ginger, Rhizoma Cyperi, lily, licorice root, Radix Codonopsis, Radix Pseudostellariae, Kawa Ko, Amomum villosum etc. The four drugs:temperature, cold, cold, cold and heat; Five flavors:bitter, pungent, sweet, sour, light, bitter, salty; Tropism: spleen, lung, liver, stomach, heart, kidney, bile, large intestine, bladder, small intestine, triple burner, pericardium; Traditional Chinese medicine types are:tonic, antipyretic, regulating qi, resolving phlegm and relieving cough and asthma relieving medicine, medicine, promoting blood circulation to remove blood stasis, astringent drug, hemostatic, diuresis Shenshi medicine, Chinese medicine, dampness, Xiaoshi drugs, sedative, warm in medicine, medicine for rheumatism, diarrhea medicine insecticidal antipruritic drugs, poison attack, anthelmintic drugs for inducing resuscitation; The core of drug combinations are:(1) dragon bone and oyster (2) Huang Lian and Wu Zhuyu (3) pinel 1 ia tuber and Codonopsis pilosula and Radix Glycyrrhizae (4) Lily and Radix Linderae (5) Bupleurum and Radix Scutellariae and Radix Paeoniae Alba (6) Nutgrass galingale rhizome,and Bupleurum; All types of commonly used drugs:Disharmony between 1 iver and stomach syndrome:Radix Paeoniae Alba, Radix Bupleuri:Rhizoma Cyperi, Radix Scutellariae, Poria, licorice, ginger, pinellia, citrus aurantium; Yin deficiency and qi stagnation syndrome:Lily, Radix Linderae, Ophiopogon japonicus, radix, Radix Paeoniae Alba, Radix Angelicae sinensis, rehmannia, medlar, Kawa Ko; spleen deficiency and dampness heat syndrome:Poria, Radix Codonopsis licorice root, largehead atractylodes rhizome, Polyporus, Amomum villosum, Costas, pinellia tuber, etc. Spleen deficiency and dampness heat syndrome:Poria, Radix Codonopsis, Radix Glycyrrhizae Preparata, Rhizoma Atractylodis Macrocephalae, Polyporus, amomum fruit, Radix Aucklandiae, Rhizoma Pinelliae; spleen stomach damp heat syndrome of commonly used traditional Chinese medicine, Rhizoma Coptidis, Radix Bupleuri, Rhizoma Pinelliae, licorice root, baikal skullcap root, perilla leaf, dried tangerine peel, bitter orange, melon, bamboo shavings; spleen deficiency and dampness heat syndrome:yellow, ginger, Scutellaria baicalensis, jujube, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Poria, pinellia, licorice root; syndrome of qi stagnation and blood stasis:zedoary, amomum fruit, white peony root, coix seed, three seven powder, Radix Salviae Miltiorrhizae; spleen and stomach weakness: Poria, Radix Glycyrrhizae, Radix Codonopsis, Radix Aucklandiae, Rhizoma Atractylodis Macrocephalae, Amomum villosum, Chen PI, pinellia tuber, Jiao Sanxian; liver stomach the stagnated heat syndrome, bupleurum, Scutellaria, Coptis, Rhizoma alismatis, cuttlebone, dried tangerine peel, Fritillaria thunbergii, white peony root, perilla leaf, Radix Gentianae, Kawa Ko etc. Disharmony between liver and spleen syndrome commonly used in traditional Chinese medicine are:Poria, Atractylodes, licorice, astragalus, dried tangerine peel, ginger, Rhizoma Coptidis, Radix Aucklandiae, honeycomb, Polyporus, Amomum villosum; Yin deficiency and heat syndrome of stagnation of commonly used traditional Chinese medicine:citrus, Jiao Binlang, was born, hemp seed, lily, cuttlebone, Scutellaria, Coptis, lotus leaf, medlar, Ophiopogon japonicus angelica, etc.Conclusion:Part1:Studies show that the efficacy of traditional Chinese medicine to improve the symptoms, Gastroscopic manifestations and pathological tissue of PLGC patients is better than western medicine, but the quality of the included literature is low, uneven design research, the lack of normative, may affect the results of meta analysis.Part2:Professor Li Zhenhua believes that the weakness of the spleen and stomach is the basic pathogenesis of PLGC, qi stagnation, blood stasis, heat and toxin, dampness as the standard, Qi spleen and stomach disorders as basic disease machine through the PLGC, development, evolution and always. According to the different pathogenesis treatment will be divided into liver regulating method, filling method, lifting method, wet, reinforcing method and advocated the macro micro mutual reference, combine traditional Chinese and Western medicine.
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