The Synthesis Of 2-heterocyclic Linked Chromones

There are a lot of compounds which includes chromones cyclic in nature. They have been interesting because they have special framework and more bioactivity. Flavones (2-phenyl chromones ) is widely in kinds of plants, and they have antifungi, anticonvulsive, antiallergic , anti-spastic, resisting cancer cell and reducing sugar-blood and fatness-blood, Vit. P′function, and so on. So this promoted it′s development in synthetic chemistry. Heterocyclic compounds, such 1,3,4-oxadiazole, 1,3,4-thiodiazole, also own to versatile and significant biological activities as fungicides, insecticides, antimicrobe, as well as plant growth regulator. A series of investigation on combining these two components often display some novel biological activities in addition to mentioned above of compounds. In view of this, the synthesis of compounds attracted more interest. But this synthesis which is from 2-formyl chromones is scantly in literatures. We induced 1,3,4-oxadiazole and 1,3,4-thiodiazole to chromones from 2-formyl chromones, and expect to build up their bioactivities. Target molecules have not reported in articles. The mainly works in this paper: 1. Substituted 2-formyl chromones reacted with aroylhydrazine to give corresponding hydrozone, then cycliced to 2-(3′-acetyl-5′-aryl-1′,3′,4′-oxadiazoline-2′-yl) chromones under acetic anhydride.2. 1,3,4-thiodiazole reacted with formyl chromones, then linked 1,3,4-thiodiazole chromones′Shiff base were prepared.