Study On The Synthesis Of 3-Substituted Chromone Derivatives And Pentosyl Guanidines

The chromone is a kind of secondary metabolic plant which has widely bioactivity. Chromones not only extracted from natural products, but synthesized by mankind, play an important role in chemistry. In study to improve the bioactivity of chromones, chemists have found that chromone linking glycosyl and heterocyclic framework have more widely bioactivity, especially at C-3 position, have very strong functions to anti-tumour, antibacterial, antivirus. So, leading other group, such as glycosyl heterocyclic framework, to chromone ,is always a hot issue in chromone research . Here, we have induced glycosyl and oxdiazoyl to chromone and get two series of new compounds, which have some bio-activities. Guanidines exist in many kinds of natural compounds. They have many significant biological activities and are widely used in chemistry researches. So, guanidines research has become another focus in organic chemistry field. Herein we report that a series new guanidines including glycosyl have been synthesized, and some of new compounds have been found have anti-HIV activitity. The structures of new compounds have been confirmed by data of elemental analysis, 1H NMR, IR and MS spectra. The biological activities of some new compounds have been proved by The National Center for Drug Screening. The mainly works in this paper: 1. Substituted 3-formylchromones reacted with glycosylthioureas derivatives to give a series of new 3-glyhydrazinecarbothioamide-methylene Chromones. Some of new compounds have been found have biological activity. 2. Substituted 3-formylchromones reacted with aroacetohydrazides to give corresponding hydrazone, which is treated with acetic anhydride to give a series of chromones with substitution of 1,3,4,-dihydraoxadiazoly in 3-position.