| Objective:To provide clinical evidence for massage treatment of obesity through meta-analysis.To summarize the manipulation rules of massage treatment for obesity through data mining.To observe the efficacy of abdominal massage combined with lifestyle intervention on simple obesity,and analyze the underline mechanism.To observe the effect of abdominal vibration on weight loss in obese mice,and reveal the biological mechanism through 16s RNA sequencing,serum metabolomics and stool metabolomics.Methods:1.Literature research:We searched for trials about massage combined with lifestyle intervention for the treatment of obesity in CNKI、VIP、Wanfang、Pub Med、Embase and Cochrane Library through 11 December 2022.After selecting literature,extracting data,and evaluating the risk of bias included in the study,a systematic evaluation and meta-analysis of the data was conducted.We searched for trials about massage for the treatment of obesity in the above databases through August 2022.After selecting literature and extracting data,a data mining study was conducted.2.Clinical research:84 patients with simple obesity were recruited.They were randomly divided into control group and treatment group.The control group was treated with lifestyle intervention,while the treatment group was treated with abdominal massage combined lifestyle intervention.The course of treatment lasted for 4 weeks.3.Animal trial:Ten of 40 male C57 mice were randomly selected as control group and given normal diet.The other 30 mice were given a high fat diet to establish an obesity model.After molding,they were randomly divided into model group,artificial abdominal vibration(AAVT)group,and mechanical abdominal vibration(MAVT)group.The course of treatment lasted for 4 weeks.Results:1.Literature research:Meta analysis:Massage can further improve the effective rate(ER)and weight loss(BW),body mass index(BMI),body fat ratio(BFR),waist circumference(WC),and triglycerides(TG)based on lifestyle interventions.Data mining:Massage treatment for simple obesity mainly focuses on abdominal manipulation.2.Clinical research:(1)BW and BMI:After treatment,BW in the treatment group and the control group decreased by an average of 2.85 kg and 1.93 kg,respectively,with BMI decreased by an average of 1.18 kg/m~2and 0.81 kg/m~2,respectively.The amount of BW reduction and BMI reduction in the treatment group changed more significantly(p<0.01).(2)WC,WHR,HC and WHt R:After treatment,WC in the treatment group and the control group decreased by an average of 3.56 cm and 0.91 cm,respectively,with WHt R decreased by an average of 0.02 and 0.01,respectively.Compared with pretreatment,WC and WHt R in the treatment group decreased more significantly(p<0.05),while there was no significant difference between WHR and HC groups(p>0.05).(3)Skin fold thickness:After treatment,the abdominal skin fold thickness in the treatment group and the control group decreased by an average of 4.00 mm and 3.26 mm,respectively,with a more significant decrease in the treatment group(p<0.05);Compared with pretreatment,there were no significant changes in the thickness of the triceps brachii skinfold and the thickness of the subscapular corner skinfold in the treatment group and the control group(p>0.05),and there was no significant difference between the groups(p>0.05).(4)Blood lipids:Compared with pretreatment,there were no significant changes in the levels of TC,TG,LDL-C,and HDL-C in the treatment group and the control group(p>0.05),and there was no significant difference between the groups(p>0.05).(5)Serum hormone level:Compared with pretreatment,there was no significant change in fasting blood glucose(FBG)levels in the treatment group and the control group(p>0.05),and there was no significant difference between the groups(p>0.05);After treatment,FINS in the treatment group and the control group increased by an average of5.28 mmol/L and 0.75 mmol/L,respectively,with GLP-1 increased by an average of 3.15pmol/L and 1.64 pmol/L,Gastrin increased by an average of 83.32 pg/m L and 39.39 pg/m L,and Leptin decreased by an average of 6.15 pg/m L and 3.61 pg/m L,respectively,indicating a significant change of FINS,GLP-1,Gastrin and Leptin in the treatment group(p<0.01).(6)The score of the SF-36:After treatment,the quality of life in both the treatment group and the control group was improved to varying degrees,and only the VT score in the treatment group was significantly higher than that in the control group(p<0.05).(7)The Obesity Related Well Being 97 questionnaire(ORWELL97)score:After treatment,the ORWELL 97 scores in the treatment group and the control group decreased by an average of 11.47 and 5.24,respectively,with a more significant decrease in the treatment group score(p<0.05).(8)The score of the simplified nutritional appetite questionnaire(SNAQ):After treatment,the SNAS scores in the treatment group and the control group decreased by an average of 1.89 and 1.50,respectively,with a more significant decrease in the treatment group score(p<0.05)(9)The score of gastrointestinal symptom rating scale(GSRS):After treatment,the GSRS scores in the treatment group and the control group decreased by an average of 5.44and 3.18,respectively,with a more significant decrease in the treatment group score(p<0.01).2.Animal trial:Both AAVT and MAVT can reduce the weight of mice body,i WAT and e WAT,improve insulin resistance(IR)of obese mice,but have limited effect on blood lipids.Both AAVT and MAVT reversed the increase of Lactococcus and Streptococcs induced by HFD diet.Compared with the model group,AAVT upregulated the levels of one lysophosphatidylcholine(Lyso PC),five lysophosphatidylethanolamines(Lyso PE),three phosphatidylcholine(PC),and glycyl-prolyl-hydroxyproline in serum,and downregulated the levels of one sphingomyelin(SM),valine and some other amino acids(p<0.05).Compared with the model group,MAVT reduced four kinds of PC and eight kinds of carnitine(p<0.05).Pyro-L-glutaminyl-L-glutamine,valine and other amino acids were down-regulated(p<0.05).After AAVT intervention,the levels of Valyl-Lysine in feces decreased(p<0.05).MAVT upregulated the levels ofγ-aminobutyric acid and(+)-threonine-2-amino-3,4-dihydroxybutyric acid in feces,while the levels of valine,lysinylvaline and some other amino acids in feces decreased(p<0.05).Conclusion:Abdominal massage has a good effect on weight loss and thinning abdomen,which may be related to the changed levels of GLP-1 and Gastrin.The mechanism of weight reduction of mice by abdominal vibration technique may be related to the regulation of Streptococcus,Lactococcus and other bacteria in the intestine,and then the regulation of fatty acids and branched chain amino acids(BCCAs)in serum and stool.Abdominal massage has a good effect on weight loss,which may be related to the changed levels of GLP-1 and Gastrin.The mechanism of weight reduction of mice by abdominal vibration technique may be related to the regulation of Streptococcus,Lactococcus and other bacteria in the intestine,and then the regulation of lipids,branched chain amino acids(BCCAs)and SCFAs in serum and feces.This also indicates that abdominal massage has the function of restoring the function of ascending the spleen qi and descending the stomach qi. |
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