Effects Of Particulate Matter On The Mechanism Of Children Asthma

Epidemiological studies have found that the prevalence of asthma increased year by year.Environmental pollution plays a key role in aggravating asthma.To assess the effects of air pollutants,age,history of allergies,family history of allergies,treatments,treatment procedures,and compliance on asthma in uncontrolled children in Xiamen,China.We retrospectively analyzed the clinical data of asthmatic children treated in the Pediatric Outpatient Department of the First Affiliated Hospital of Xiamen University from January 2016 to June 2018.A total of 3268 patients were screened based on the prognostic evaluation of fully controlled,partially controlled and uncontrolled patients.After rank sum test,age,allergic history,family allergic history,season,treatment steps,and compliance were all related to the uncontrolled rate(P<0.001).Logistic regression analysis showed that PM10,NO2,and SO2 decreased the rate of asthma control.The effect of seasons on the uncontrolled rate of asthma is spring,autumn,and summer in descending order.We also evaluated the short-term effects of particulate matters on exacerbations in children.Using the case-crossover design,the short-term effects of PM exposure on asthma exacerbation in 3106 child outpatients were evaluated.The results found that exposure to PM2.5 and PM10 over the past two weeks were significantly associated with an increased-exacerbation risk of asthma.Both PM10 and PM2.5 exposure time have significant short-term effects on asthma exacerbation in children;PM10 could decreased the rate of asthma control,while PM2.5 had no significant correlation with the rate of asthma control.Hence,the exposure concentration and time of PM can be used as epidemiological parameters for clinical management of asthma exacerbations risk in sensitive populations.Based on the above studies,in order to further study the regulatory mechanism of PM immunogenicity.Gene-chip analysis was performed on 171 healthy people’s peripheral blood from northern cities,and transcriptional regulators IRF4 and STAT3 related to PM exposure were identified.To verify the role of the selected transcription factors,we used T cell culture and PM-treated mice for in vivo and in vitro experiments.It was confirmed that the activation of IRF4 and STAT3 is closely related to the imbalance of T cell differentiation in mouse respiratory tract.Therefore,IRF4 and STAT3 may be regulators of PM respiratory latent inflammation,and our results help reveal the biological background of PM immunogenicity.