Clinical Efficacy Of A Combination Treatment With DPL And CO₂ Fractional Laser On Color Of Hypertrophic Scar

OBJECTIVETo demonstrate the efficacy and safety of combining Dye Pulse Light（DPL,narrow-spectrum intense pulsed light 500-600nm）and CO2fractional laser for the treatment of Hypertrophic Scar Color.METHODSBetween January 2015 and June 2017,3494 patients with hypertrophic scar were treated standardly with 3 times of a combining DPL and CO₂ fractional laser at 2-3 months intervals in Shanghai JiaoTong University School of Medicine Shanghai Ninth People’s Hospital.Photographs were taken before each treatment and after 3months of the last treatment.The Visual Analogue Scale（VAS）,there parameters（L*a*b*）and color difference(ΔE*₉₄)measured by photography and CIELAB color space,and the assessment of side effects were investigated for clinical efficacy and safety.Data analyzed by SPSS25.0 t test,P<0.05 means different,P<0.001 means significantly different.RESULTSAfter 3 times treatments,L*values of hypertrophic scars increased from 59.18±7.08 to 67.47±7.92,a*values decreased from 23.43±4.45 to17.39±3.41,b*values decreased from 14.41±4.39 to 13.86±4.21,and ΔE*₉₄ decreased from 18.79±7.12 to 10.15±6.78.Those results indicated that hypertrophic scars were lighter,less red after treatments,and were a statistically significant difference between pre-and post-treatments（P<0.001）.Besides,VAS score decreased from 8.88±2.90to 3.51±1.96,which was a statistically significant difference between pre-and post-treatments（P<0.001）and indicated that the rigidity,thickness,texture and hyperemia of hypertrophic scars improved after treatments.Furthermore,side effects were limited to pigmentation and erythema and the incidence of side effects was 0.13%.Moreover,82.54%of patients were satisfied about the efficacy of treatments.CONCLUSIONSThe combination of DPL and CO2 fractional laser is an potential effective and safety resource for the improvement of hypertrophic scar color.