Overexpression Of DOCK2 Correlates With Good Prognosis In Colorectal Cancer Associated With More Prominent CD8+ Lymphocytes Infiltration:A Tissue Microarray Analysis

Recently,DOCK2 has been reportedly exhibited high mutation prevalence in the Asian colorectal cancer(CRC)cohort.However,the expression pattern of DOCK2 and its clinical significance in CRC were still unknown.In order to characterize the role of DOCK2,a tissue microarray(TMA)containing 481 archived paraffin-embedded CRC specimens was performed by immunohistochemistry.Among which,54 primary colorectal cancer tissues showed high expression of DOCK2 protein,while others were negative.Moreover,DOCK2 expression was positively associated with invasion depth(p< 0.001)and tumor size(p=0.016).Significantly,Kaplan-Meier survival analysis revealed that patients with higher DOCK2 expression had a longer overall survival time(p=0.017).Furthermore,univariate and multivariate Cox regression analysis confirmed that DOCK2 is an independent prognostic marker in colorectal cancer(p=0.049,HR=0.519,95% CI:0.270-0.997).In addition,we observed a strong correlation between the infiltration of CD8+ T lymphocytes and DOCK2 expression(p=0.0119).Our findings demonstrated that overexpressed DOCK2 might involve in recruiting CD8+ T lymphocytes and serve as a novel prognostic indicator and indicated a potential therapeutic strategy by restoring DOCK2 for CRC.