The Clinical Observation Of Treating Irritable Bowel Syndrome Which Belongs To The Dampness Stagnancy Due To Spleen Deficency Tupe By Jiuxiening Granula

Objective:Through searching,screening and analysis of database retrieval relevant literature in Chinese,traditional Chinese medicine for nearly 15 years is used in the treatment of diarrhea type irritable bowel syndrome of related literature,summarized the TCM etiology and pathogenesis of the disease,the law and the relevant intervention methods,design randomized controlled trial at the same time,using relevant life quality evaluation scale,evaluation of jiuxiening granule on diarrhea type irritable bowel syndrome clinical efficacy and safety of drug,traditional Chinese medicine for treatment of diarrhea type irritable bowel syndrome scheme to offer reference to the further optimization,for a long time xie ning granules of laying a foundation for clinical applicationMethods:Through the computer retrieval 15 years from 2000 to 2014,ten thousand party,d popularization of tsinghua tongfang hownet database published in Chinese medicine for the treatment of diarrhea type irritable bowel syndrome related literature.According to include and exclude standard screening and sorting,title,name of TCM,syndrome differentiation,treatment methods into Microsoft Excel in Excel 2010 form,establish total database,and then create four sub database according to the research purpose,again USES the frequency statistics,association analysis method to the treatment of diarrhea type irritable bowel syndrome of traditional Chinese medicine clinical symptoms,syndrome classification,the characteristic,the frequency of usage of Chinese traditional medicine,drug commonly used to the theory,commonly used prescription and drug usage between syndrome type and other information for statistical analysis.(2)would be consistent with clinical diagnosis standard and included in the standard case of this study,128 patients according to the random scale,divided into the treatment group 64 examples,the control group(n=64).Oral treatment,treatment group with long ning granules in the control group given Belly pain away,continuous treatment,and observe three weeks on two groups of clinical curative effect.Chinese medicine syndrome curative effect,symptom improvement and adverse reaction and safety indicators were compared..Results:1.1 319 were retrieved from relevant literature,according to the inclusion criteria,exclusion criteria of limit,get 614 paper,involving 186 kinds of drugs,drug use frequency of the total is 6193 times;Containing Chinese medicine prescription 560 zhang,one of the characteristics of 103 prescriptions,can query to the source,this formula using the total frequency of 1576 times;Choose to study in the literature contains symptoms of 97,symptoms appear the frequency is 3815;Contains the syndrome of 46,syndrome of total frequency of 438 times.Been waiting decomposition and frequency analysis,syndrome elements combination frequency 734 times,including documents,15 kinds,two syndrome elements combination of 12.3 card 5 kinds of element combinations.2.The analysis results show that the frequency of clinical commonly used a total of 29 kinds of frequency is higher than 80 drugs,these drugs are dangshen(254),atractylodes(176),radix bupleuri(172),platycodon grandiflorum(159).rhubarb(139),dried tangerine or orange peel(135);Commonly used medicine species is tonify deficiency(1257),and qi(1106),the water moisture penetration medicine(942),promoting blood circulation to remove-blood stasis drugs(882),temperature in medicine(632),phlegm cough antiasthmatic(547),including virtual drugs commonly used drugs for dangshen,atractylodes,radix paeoniae alba,radix glycyrrhizae,radix astragali,facilitating commonly used drugs for dried tangerine or orange peel,sweet,sweet,bitter orange,radix linderae,the water moisture penetration drug commonly used drugs for poria cocos,plantain seed,rhizoma alismatis,coix seed,money grass.Commonly used drugs,four gas with warm(164),lukewarm(154),flat(145)is given priority to,cold and heat drugs is less;Five commonly used drugs to f(208),bitter(188)and(172),followed by acerbity(48),salt(25).acid(18),light(9)is complementary.3.Choose three refs atractylodes dispersion(214),and(193),plum pill(173),four gods pill(164),(143),the principle of with puerariae and scutellariae and coptidis decoction pill(139).4.The high frequency of symptoms are divided into abdominal distension(286),stay(265),diarrhea(244),abdominal distension(232),bowel(224),constipation(204);Occurrence frequency of more than 10 TCM syndrome types,a total of eight,qi deficiency of spleen and stomach syndrome(73),spleen kidney Yang deficiency(63),change the certificate(54),liver depression and qi stagnation syndrome(25),spleen and stomach deficiency cold syndrome(12),fever syndrome(12)mixed,e.deficient syndrome(12),tianjin,spleen and stomach Yin deficiency syndrome(11).5.The element analysis,with 20 times greater than the frequency of documents 10,followed by qi deficiency(220),qi yu(190),in the wet(163),Yang(76),internal heating frequency(37),jin kui(37),blood deficiency(37),blood stasis(34),Yin deficiency(28),and qi(25),the cumulative frequency of 90.8%.The two syndrome factor combination of more than 10 frequency is deficiency of qi depression(73),deficiency in wet(56 frequency),the wet internal heating(43),Yang deficiency in cold(32),cold heat(27),qi depression and qi stagnation(10);Three certificates,low frequency at the same time,for the deficiency of qi congestion stasis(16),qi deficiency qi depression in wet certificate(13),internal heating Yin deficient syndrome(6),tianjin qi deficiency,Yang deficiency in wet card(6),Yang deficiency in cold dampness syndromes(3).6.Correlation analysis showed that the clinical treatment to use more drugs to the party involved in liquorice(26.9%),radix bupleuri and radix paeoniae alba(25.6%),atractylodes and codonopsis pilosula(205.4%),dried tangerine or orange peel and poria cocos(24.8%),wind and radix paeoniae alba(23.8%).7.That is associated with spleen deficiency syndrome of drug combination,support more than 10%of drug combinations are extracted and codonopsis pilosula(17.0%),the party involved in radix bupleuri(15.1%),lotus seed and yam(14.4%),the party involved in malt(13.0%),poria cocos and licorice root(13.0%),etc.;Combination of drugs is associated with the spleen kidney Yang deficiency syndrome,support more than 10%of drug combinations are mainly atractylodes and nutmeg(18.3%),malaytea scui-fpea fruit and nutmeg(16.4%),the party involved in fructus schisandrae(15.7%),atractylodes and evodia rutaecarpa(14.3%),lateral root and atractylodes(14.3%),etc.8.Compared with before treatment,the treatment group and control group in improving their overall efficacy Ridit analysis,Ridit analysis of syndromes,signs and symptoms integral,the integral quality of life,the main symptom integral,etc.,there are differences,with statistical significance(P<0.05).9.Compared with control group,treatment group in the overall efficacy Ridit analysis,Ridit analysis of syndromes,signs and symptoms,quality of life,integral etc,there are differences,with statistical significance(P<0.05);Traits in stool,abdominal distension,abdominal pain,limb bowel,drowsiness,god to improve symptoms such as fatigue,significant differences in treatment group and control group(P<0.05);In the loss of appetite,less gas lazy words such as improvements in symptoms,treatment group and control group there was no significant difference(P>0.05).10.For three months follow-up after treatment,compared with control group,treatment group in the overall efficacy Ridit analysis,signs and symptoms,quality of life score differences,with statistical significance(P<0.05).11.The treatment group and control group in blood,urine,dung routine and liver and kidney function not found significant changes.Conclusion:1.The treatment of irritable bowel syndrome of TCM clinical commonly used dangshen,atractylodes,radix bupleuri,drugs;The commonly used medicine for the party participate in licorice,radix bupleuri,radix paeoniae alba and atractylodes and dangshen,Types of commonly used drugs is tonify deficiency medicine,facilitating agent,water moisture penetration;Commonly used drugs,four gas is given priority to with warm,lukewarm,flat;Five commonly used drugs is given priority to with sweet,bitter,bitter;Is the most commonly used formula and scattered,and three atractylodes,plum pill,four god pill,pill,science with puerariae and scutellariae and coptidis decoction.2.The doctor of traditional Chinese medicine in the treatment of irritable bowel syndrome,the most common symptom is abdominal distension,stay bowel,constipation,diarrhea,abdominal distension,;Syndrome differentiation and treatment of the most common type witness to spleen and stomach qi deficiency syndrome,spleen kidney Yang deficiency syndrome,liver spleen def ciency and liver depression and qi stagnation syndrome,spleen and stomach deficiency cold syndrome,fever,mixed disease involving the liver,spleen,kidney,intestine,stomach,and other viscera;Split syndrome and syndrome factor decomposition and found documents mainly qi deficiency,qi depression,in the wet,Yang deficiency,internal heat,two qi deficiency syndrome factor combination mainly qi depression,deficiency in wet,wet heat,Yang deficiency in the cold,cold heat,three certificates,low frequency at the same time,mainly for the deficiency of qi congestion stasis syndrome,qi deficiency qi depression in wet and internal heating Yin jin kui qi deficiency Yang deficiency in dampness syndromes,Yang deficiency cold dampness syndromes,it reflects the irritable bowel syndrome often witness pathogenesis characteristics,as well as the clinical syndrome differentiation with qi deficiency,qi depression syndrome is seen.(3)in the treatment of irritable bowel syndrome of traditional Chinese medicine syndrome cure law,drug combination,associated with spleen deficiency syndrome mainly include atractylodes and dangshen,the party involved in radix bupleuri,lotus seed and yam,the party involved in malt,poria cocos and licorice drug compatibility structure;That is associated with the spleen kidney Yang deficiency syndrome of drug combinations are mainly atractylodes and nutmeg,malaytea scurfpea fruit and nutmeg,the party involved in fructus schisandrae,atractylodes and evodia rutaecarpa,atractylodes drugs and radix aconiti lateralis praeparata structure.The above research results follow the rules of "medicine-certificate",in this studv of syndrome classification,the frequency and statistical results,the most commonly used drugs and conform to the clinical practice,this research method is believable.4.This study collected the treatment of irritable bowel syndrome of TCM philology,using data mining methods,get drugs classification,sexual flavour,symptom,syndrome and syndrome factor decomposition and frequency statistics results,combined with drug-drug,the drug-card association rules analysis results show that the results are in good consistency between prescription selected drug to the pathogenesis of irritable bowel syndrome in accordance with "pathogenesis prescription-use" traditional Chinese law,suggests that this research method is accurate,believable results.Of traditional Chinese medicine in the treatment of irritable bowel syndrome,from "empty,depressive,cold,wet" theory,from the spleen,kidney,liver and other viscera,follow the "tonify deficiency,liver,explored,"cold treatment prescription is to tonify deficiency such as medicine,facilitating medicine,water treatment such as medicine,promoting blood circulation to remove blood stasis drugs.5.Jiuxiening granule is the treatment of diarrhea type irritable bowel syndrome wet pixu(spleen deficient)syndrome in patients with effective prescription,can significantly improve the patients’ clinical symptoms and signs,syndromes,to provide the patient’s quality of life,especially in the stool properties,abdominal distension,abdominal pain,limb bowel,drowsiness,fatigue the improvement of clinical symptoms,such as god is better than that of Belly pain away group,curative effect.Jiuxiening granules in the clinical use 3 weeks during observation period,no side effects,and other adverse reactions report found.