Clinical And Experiment Research On The Treatment Of Kidney-YANG Deficiency KOA With XINING Formula

Osteoarthritis affects a significant proportion of the Chinese population and theresulting loss of articular cartilage and severe pain and disability. There are no effectivetreatments for repair of the damaged articular cartilage in these diseases and while theirlikely aetiologies are very different. How to partially repair the articular cartilage is theleading thought of the study by TCM.The dissertation was to explore the rabbit knee joint osteoarthritis (KOA) model ofKidney-YANG deficiency which was made by the method of compound causes of diseaseaccording to the TCM’s theories of attack, clinical manifestation and physiological andpathological characteristics of modern diseases about this syndrome, and to acquire theChinese medicine syndrome and some biological characteristics of this model throughobserving many targets about the second messenger, hormone level, cytokine, pathologicalcharacteristics bone samples ultramicrostructure and so on, which was indwelled in therabbit’s blood plasma and serous. On these achievements, the actions from the XININGFormula and JingKuiShenQi Bill which were administrationed into the KOA rabbit’smodels were abserved and compared to investigate the biological effects and the relevancebetween the models of disease and syndromes on the condition of different prescription onthe same syndrome. On these grounds, the dissertation was to provide substantial basis forfurther revealing and exploring the theories of TCM.The dissertation contained of documental summarization, clinical research andlaboratory study. The documental summarization contained of successive changes fromSpring & Autumn and Warring States Periods to Qing Dynasty of the theories of TCMabout KOA, the basis of argumentation about XINING Formula, modem models aboutsyndrome of deficiency of Kidney-YANG. We can reveal the causes of the question forstudy and investigate the origin of the theory about the study as well as the feasibility of theoperation about the KOA models. 42 patients’ samples with KOA of Kidney-YANGdeficiency were selected and randomized into the group of XINING Formula and the group of Meloxicam for clinical research. To evaluate the therapeutic effects of the two sets afteradministration on the basis of the scores of pain evaluated by patients privately, the scoresof clinical signs and symptoms, the scores of symptoms of TCM, and so on. The therapeuticeffects were similar between the group of XINING Formula and Meloxicam, the group ofXINING Formula improved the KOA patients’ scores of pain and ameliorated the knee jointfunction. The XINING Formula had an advantage over Meloxicam about partial indexes ofsyndromes of TCM. The XINING Formula’s medicine adverse reactions were lower thanMeloxicam’s afer therapy. Laboratory study initiated primarily from the acute toxicity testto nerve-endocrine-immunity system, anti-inflammatory and relieve pain test,microcirculation test. On these achievements, the KOA rabbit’s models manifested theresembled systems of Kidney-YANG deficiency which hinted to the molecule’smanifestations according to modern TCM theories and laboratory study as well ascytokines, inflammantory idexes of osteoarthritis. All of these molecule changesdemonstrated the models were made successfully. XINING Formula can ameliorate manyindexes of the immunology and osteoarthritis’s cytokines, inflammatory by theKidney-YANG deficiency KOA rabbit models experimental study.Conclusions: Kidney-YANF deficiency KOA rabbit models were made successfully.Experimental study demonstrated XINING Formula could ameliorate laboratory indexes ofthe rabbit models. Clinical research demonstrated XINING Formula could ameliorate theKOA patients symptoms and signs. All of these demonstrations revealed the TCM’smechanism of action and TCM symptoms’ basis of biology laboratory. We discuss theprobable mechanism of therapeutic effect of XINING Formula on OA, so as to get a deepunderstand in the rationale of using XINING Formula as a choice in the prevention andtreatment work of osteoarthritis in clinical work, to enhance the KOA patients quality oflife, to decrease the KOA patients disable ratio, to provide favourable approaches to studyTCM.