The Association Between Polymorphisms In Pro-or Antioxidant Enzymes（MPO, SOD₂and CAT） Genes And Prostate Cancer Risk In Chinese Population

[Background] The incidence of prostate cancer (PCa) was higher in the U.S. and Europe, lower in Asian populations. It increased considerably in China in the last decade, likely due to the improvement of PCa diagnosis and PCa screening, aging of the population, and westernized life style. It is the fifth highest incidence of cancer in men in Shanghai and becomes a major public health concern. To date, the molecular mechanism of PCa is unclear which limits our ability to effectively prevent and treat the disease. Oxidative Stress has association with Prostate cancer (PCa). The expression of pro-or antioxidant enzymes (MPO, SOD2and CAT) has been correlated with gene polymorphisms. Our study aimed to evaluate the association between the genetic polymorphisms and the risk of prostate cancer.[Method] Genotyping was carried out by using the genotyping system (MassARRAY iPLEX; Sequenom, Inc., San Diego, CA, USA) on1,388PCa patients and1,008cancer-freecontrols in a Chinese population.[Result]One SNP of SOD2(rs5746136, P<0.050, OR=0.8806=was significant. Another SNP showed a limited association with PCa risk (rs554518, P=0.09443) in all SNPs of CAT. Other SNPs had no significant difference between genotype distributions in the PCa patients and the control group.[Conclusion] Our data showed that rs5746136of SOD2has association with the susceptibility to PCa in population of Chinese. This provide a clue of the diverse responses to antioxidants in the treatment and prevention of PCa.