Association Of Genetic Variants With Prostate Cancer In Chinese Population

Background Prostate cancer is the second leading cause of cancer death in Americans. Asian Chinese have a low prostate cancer risk. however, in the absence of screening practices for the disease, most are diagnosed with metastatic prostate cancer. Recently, several different common variants on chromosomes have been shown to be associated with prostate cancer in multiple studies and ethnic groups. Single-nucleotide polymorphisms (SNPs)—rs1447295 8q24,rs4430796 17q,rs6983267 8q24,rs7210482 2p15,rs16901979 8q24,rs1859962 17q,rs5945572 Xp11.22 in seven chromosomal regions—three on 8q24 and one each on 17q12 and 17q24.3 and one on Xp11.22 and one on 2p15—have been associated with prostate cancer.The objective of this study was to confirm the association of the seven SNPs with prostate cancer in Chinese population.Methods We evaluated seven SNPs from seven chromosomal regions in a population (99 subjects with prostate cancer and 99 age-matched control subjects (Southern China), and assessed the individual association of the SNPs with prostate cancer in Chinese population.Results Overall, rs1447295,rs4430796,rs6983267,rs7210482 were significant association with prostate cancer [odds ratio (OR), 1.684; 95% confidence interval (95% CI), 1.002-2.830],[odds ratio (OR), 0.594; 95% confidence interval (95% CI), 0.364-0.969],[odds ratio (OR), 1.597; 95% confidence interval (95% CI), 1.008-2.531],[odds ratio (OR), 2.622; 95% confidence interval (95% CI), 1.051-6.524](P<0.05);but no significant association with rs16901979,rs1859962,rs5945572 with prostate cancer (P >0.05).Conclusions We conclude that Rs1447295 8q24,rs4430796 17q,rs6983267 8q24,rs7210482 2p15 might be associated with prostate cancer in Chinese population.