Based On Data Mining Technology Of "pharmacopoeia Of Internal Medicine And Some Prescriptions Efficacy Research

Objective:summarize and conclude the medication rule of internal herbs, explore the methods for determining the tendency of effects based on the properties of herbs.Methods:do research on the collected prescriptions from the first volume to the sixth volume of Prescriptions of Peaceful Benevolent Dispensary, create the data tables by using Microsoft Excel software, apply clustering approach to find the characteristics of drug therapy of prescriptions in each volume, discover frequent couplet herbs in prescriptions of each volume by association rule mining approach and analyze the experimental results from the aspect of traditional Chinese medicine based on literatures, propose the attribute distance matrix and use it to predict the tendency of effects in Prescriptions of Peaceful Benevolent Dispensary, design a mathmetical model to induce the effects of prescriptions from herbs and use it to reduce the useless effects.Results:(1) Medication rule:In Zhu Feng Jiao Qi volume, the frequently used herbs mainly contain herbs for relieving exterior syndromes, curing deficiency, promoting blood circulation for removing blood stasis, relieving spasm by calming endogenous wind, removing phlegm, clearing heat, warming interior, and inducing resuscitation; the core herbs include Radix Saposhnikoviae, Radix Aconiti, Rhizoma Ligustici Chuanxiong, Rhizoma Arisaematis, Rhizoma Gastrodiae, Cinnabaris, Moschus, Rhizoma et Radix Notopterygii, Bombyx Batryticatus, and Rhizoma Typhonii; the frequent couplet herbs are Radix Saposhnikoviae and Rhizoma et Radix Notopterygii, Rhizoma Gastrodiae and Moschus, Radix Saposhnikoviae and Rhizoma Gastrodiae, Radix Saposhnikoviae and Rhizoma Ligustici Chuanxiong, Moschus and Borneolum Syntheticum, Radix Saposhnikoviae and Radix Ginseng. In Shang Han Zhong Shu volume, the frequently used herbs mainly contain herbs for relieving exterior syndromes, curing deficiency, removing dampness, removing phlegm, warming interior, activating qi, promoting diuresis, and clearing heat; the core herbs include Pericarpium Citri Reticulatae, Herba Ephedrae, Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Cortex Cinnamomi, Radix Angelicae Dahuricae, Radix Puerariae, Radix Platycodonis, and Rhizoma Zingiberis; the frequent couplet herbs are Pericarpium Citri Reticulatae and Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae and Radix Platycodonis, Rhizoma Pinelliae and Cortex Magnoliae Officinalis, Herba Ephedrae and Cortex Cinnamomi, Pericarpium Citri Reticulatae and Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae and Rhizoma Atractylodis. In Yi Qie Qi Pi Wei Ji Ju volume, the frequently used herbs mainly contain herbs for warming interior, activating qi, curing deficiency, removing dampness, promoting blood circulation for removing blood stasis, removing phlegm, and promoting diuresis; the core herbs include Rhizoma Zingiberis, Radix Aucklandiae, Pericarpium Citri Reticulatae, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Ginseng, Rhizoma Atractylodis Macrocephalae, Flos Caryophylli, Fructus Amomi Villosi, and Rhizoma Curcumae; the frequent couplet herbs are Radix Ginseng and Rhizoma Atractylodis Macrocephalae, Radix Aucklandiae and Flos Caryophylli, Rhizoma Zingiberis and Radix Ginseng, Pericarpium Citri Reticulatae Viride and Pericarpium Citri Reticulatae, Rhizoma Zingiberis and Cortex Cinnamomi. In Tan Yin Ke Sou volume, the frequently used herbs mainly contain herbs for curing deficiency, removing phlegm, warming interior, relieving cough and relieving asthma, activating qi, relieving exteriot syndromes, and astringing; the core herbs include Rhizoma Pinelliae, Radix Ginseng, Pericarpium Citri Reticulatae, Rhizoma Zingiberis, Cortex Cinnamomi, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis, Cortex Mori, Rhizoma Atractylodis Macrocephalae, Herba Asari, Poria, Rhizoma Arisaematis, and Flos Farfarae; the frequent couplet herbs are Rhizoma Pinelliae and Pericarpium Citri Reticulatae, Rhizoma Zingiberis and Rhizoma Atractylodis Macrocephalae, Radix Ginseng and Fructus Schisandrae Chinensis, Radix Ginseng and Cortex Mori, Rhizoma Pinelliae and Alumen, Rhizoma Zingiberis and Pericarpium Citri Reticulatae, Rhizoma Pinelliae and Rhizoma Zingiberis, Rhizoma Pinelliae and Radix Ginseng. In Zhu Xu Gu Zheng Gu Leng Xiao Ke volume, the frequently used herbs mainly contain herbs for curing deficiency, warming interior, promoting diuresis, and activating qi; the core herbs include Cortex Cinnamomi. Radix Aconiti Lateralis Preparata, Poria, Radix Ginseng, Radix Rehmanniae Preparata, Radix Astragali seu Hedysari, Radix Morindae Officinalis, Fructus Foeniculi, Herba Cistanches, Fructus Psoraleae, Radix Achyranthis Bidentatae, and Cinnabaris; the frequent couplet herbs are Radix Ginseng and Poria, Cortex Cinnamomi and Radix Aconiti Lateralis Preparata, Radix Ginseng and Radix Astragali seu Hedysari, Cortex Cinnamomi and Radix Ginseng, Radix Aconiti Lateralis Preparata and Rhizoma Zingiberis. In Ji Re Xie Li Mi Se volume. the frequently used herbs mainly contain herbs for curing deficiency, clearing heat, astringing, warming interior, activating qi, promoting diuresis, and purgating; the core herbs include Rhizoma Zingiberis, Pericarpium Papaveris, Radix Angelicae Sinensis, Radix Aucklandiae, Semen Myristicae, Radix et Rhizoma Rhei, Fructus Chebulae, Natrii Sulfas, Radix Ginseng, Pericarpium Citri Reticulatae, Rhizoma Coptidis, Cortex Cinnamomi, and Cinnabaris; the frequent couplet herbs Rhizoma Zingiberis and Pericarpium Papaveris, Rhizoma Zingiberis and Semen Myristicae, Pericarpium Papaveris and Radix Angelicae Sinensis, Pericarpium Papaveris and Pericarpium Citri Reticulatae, Rhizoma Zingiberis and Pericarpium Citri Reticulatae, Radix Aucklandiae and Semen Myristicae, Rhizoma Zingiberis and Radix Angelicae Sinensis.(2) Prescription effect determination:applying the average value, steepest descent, Lagrange mean value, and information quantity to reduce the useless effects of formulae based on ten well-known internal prescriptions in Prescriptions of Peaceful Benevolent Dispensary, the experimental results show that the results obtained by these four approaches are independent with each other and the proposed methods for effect reduction can be applied to distinct situations.Conclusions:(1) The tendency of herb usage is closely related to etiology and pathogenesis of primarydiseases in each volume, which shows the basic idea of compatibility of prescriptions. The majority of core herbs have the property of pungent and warm, which verifies that herbs used in Prescriptions of Peaceful Benevolent Dispensary are bias to febrile dryness. But, emphasizing on using febrile dryness herbs is effacted by social environment at that time, which has the distinct characteristics of the times. In addition, the channel tendency of core herbs in each volume confirms to the viscera where disease exists in that volume. The identified frequent couplet internal herbs in Prescriptions of Peaceful Benevolent Dispensary by using association rule mining approach are generally formed by combining a pair of frequent herbs in each volume. The frequent couplet herbs reflect the characteristic of treatment and compatibility law of prescriptions. Furthermore, assorting which kind of herb is one of the important factors to control the influence of effects.(2) Applying attribute distance matrix to predict the tendency of effects in Prescriptions of Peaceful Benevolent Dispensary is verified to be accurate and reliable. It is of great practical value in the rearch of antient literatures.