Study On Prescription Rule Of Professor Jiang Baihua In Treating Cough Variant Asthma Based On Data Mining

Objective:This study analyzes Professor Jiang Baihua’s case prescription for the clinical treatment of patients with cough variant asthma through the analysis software of traditional Chinese Medicine Inheritance auxiliary platform 3.0,summarizes Professor Jiang Baihua’s prescription medication characteristics and academic thought for the treatment of cough variant asthma,and excavates the core prescription in order to truly guide clinical practice.Methods:the patients who met the diagnostic criteria of cough variant asthma in the outpatient department of Professor Jiang Baihua of Heilongjiang traditional Chinese medicine hospital from January 2020 to June 2021 were collected in the form of "outpatient medical records",and the patients whose curative effect was determined to be controlled and effective within the observation period(≤ 3 weeks)were selected.The patient medical records were standardized and entered into the "CVA database" established through Microsoft Excel,Upload this database to the analysis software of TCM inheritance auxiliary platform 3.0 for data analysis.Results:1.screening case results ResultsA total of 204 patients with CVA who met the diagnostic criteria were included in this study,including 6 cases of falling off during treatment,2 cases of patients who did not return for follow-up,3 cases of patients who had aggravated symptoms during medication and treated with western medicine on their own,and 1 case of patients who continued to take medicine after stopping medication for more than 10 days.During the observation period(≤ 3 weeks),there were 198 self controls before and after the actual completion of treatment.Among them,71 patients were clinically controlled,accounting for 35.86%;96cases(48.48%)were markedly effective;27 cases were effective,accounting for 13.64%;There were 4 ineffective patients,accounting for 2.02%,the control and display rate was84.34%,and the total effective rate was 97.98%.There were 167 patients with clinical control and significant effect.2.Frequency analysis resultsIn this study,167 prescriptions were screened,involving 107 traditional Chinese medicines,with a cumulative frequency of 4959 times.There were 31 traditional Chinese medicines with a frequency of more than 60 times,with a total frequency of 4459 times,accounting for 89.92% of the total frequency.There are 19 traditional Chinese medicines with a frequency of more than 150 times.According to the order of frequency from high to low,they are Atractylodes macrocephala,mint,Astragalus membranaceus,tangerine peel,Cinnamon Twig,Salvia miltiorrhiza,loquat leaf,white peony,Fangfeng,licorice,Platycodon grandiflorum,Fructus aurantii,Codonopsis pilosula,Stemona,cicada decidua,oyster,coix seed,Peucedanum,Scutellaria baicalensis;There are 12 traditional Chinese medicines with frequency < 60 and frequency < 150.According to their frequency,they are Schisandra chinensis,Fructus Cnidii,Fritillaria thunbergii,aster,trichosanthin,Poria cocos,red peony,Shegan,yam,reed root,Ligusticum chuanxiong and Terminalia chebula.The categories of traditional Chinese medicine are mainly Qi tonifying drugs,phlegm resolving,cough relieving and asthma relieving drugs,surface relieving drugs,heat clearing drugs,blood activating and stasis removing drugs,Qi regulating drugs,astringent lungs and intestines,diuresis and detumescence.The four Qi of medicine are mainly cold,warm and flat;The five flavors are mainly bitter,sweet and pungent,supplemented by sour;It mainly belongs to lung,spleen,liver and stomach meridian.3.Results of drug association analysisUnder the condition of high support and confidence,the number of data derived from this study is still very large,which is closely related to the drug structure and the number of prescription drugs entered in the prescription.Therefore,it can be seen that the input prescription structure of this test is relatively fixed,there are many prescriptions,and there is a close correlation between drugs.Therefore,the final correlation analysis results of this study are displayed in the form of network display diagram.When the support degree is 160 and the confidence degree is 0.95,the correlation diagram includes a(drug combination a,hereinafter referred to as a,and so on B,C,D...): Astragalus membranaceus,Codonopsis pilosula,Atractylodes macrocephala,Cinnamon Twig,Paeonia alba,Fangfeng,licorice,Platycodon grandiflorum,Fructus aurantii,Salvia miltiorrhiza,mint,loquat leaf and tangerine peel;Support 155,confidence 0.95,including B: a + Stemona,cicada molt,coix seed and oyster;Support 150,confidence 0.95,including C: B + Peucedanum and Scutellaria baicalensis;Support 145,confidence 0.95,including D: C + Schisandra chinensis;Support 140,confidence 0.95,including e: D + Fritillaria thunbergii and Fructus Cnidii;Support 135,confidence 0.95 includes F: e + aster,support 130,confidence 0.95 includes J: F + trichosanthin,and support 130,confidence 1 includes h,which is the same as J.4.Results of prescription cluster analysisThrough the experiment,the most suitable cluster numbers are 9 and 10.When the number of clusters is 9,9 core prescriptions are obtained,of which 9 core prescriptions include the drug group(Astragalus membranaceus,Codonopsis pilosula,Cinnamon Twig,Paeonia alba,Atractylodes macrocephala,Fangfeng,mint,cicada molting,Fructus aurantii,Platycodon grandiflorum,Stemona,loquat leaves,Salvia miltiorrhiza,oyster and licorice),of which the frequency of group 8 is the highest,and group 8 also includes the drug group(coix seed,tangerine peel,Schisandra chinensis,Scutellaria baicalensis and peucenta).When the number of clusters is 10,10 core prescriptions are obtained,of which 10 core prescriptions include the drug group(Astragalus membranaceus,Codonopsis pilosula,Cinnamon Twig,Paeonia alba,Atractylodes macrocephala,Fangfeng,mint,cicada molt,Scutellaria baicalensis,Fructus aurantii,Platycodon grandiflorum,Stemona,loquat leaf,coix seed,tangerine peel,Salvia miltiorrhiza,oyster and Gancao),of which the frequency of Formula 1 is the highest for 60 times,and formula 1 also includes the drug group(Peucedanum,Cnidium).5.core prescriptionBy comprehensively analyzing the results of association rules and cluster analysis,the final core drug group J is obtained.Therefore,the new formula of this core drug group is formulated as compound cough relieving formula: Astragalus membranaceus,Codonopsis pilosula,Atractylodes macrocephala,Cinnamomum cassia,white peony,Fangfeng,licorice,Platycodon grandiflorum,Fructus aurantii,Salvia miltiorrhiza,mint,loquat leaf,orange peel,Stemona,cicada slough,Coix job’s tears,oyster,Peucedanum praeruptorum,Scutellaria baicalensis,Schisandra chinensis,Fritillaria thunbergii,Fructus Cnidii.Conclusion:1.The compound cough relieving prescription is strictly compatible with the whole prescription,which can be used to supplement the middle as well as the sparse,and the middle of the circulation is combined with the tonic.It is mainly used to invigorate the spleen and lungs,expel wind and relieve spasm,supplemented by the functions of resolving phlegm and dampness,removing blood stasis and dredging collaterals,taking into account the three internal organs of lung,spleen and liver,and treating both symptoms and symptoms.The compatibility of various drugs can remove wind,remove Qi,smooth phlegm and stop cough.2.Professor Jiang Baihua believes that the main pathological factors of cough variant asthma are wind,phlegm and blood stasis.Wind evil is the leader of external evil.The main pathogenesis is Qi deficiency,excessive wind and phlegm entering the collaterals.The disease is mainly closely related to the lung,spleen,stomach and liver.For the elderly and weak,the kidney qi is gradually deficient and does not heal for a long time.It can gradually progress to asthma,and the diseased viscera can also accumulate kidney and heart.3.Professor Jiang Baihua paid close attention to four key points in the treatment of cough variant asthma: cultivating soil and generating gold,dispelling wind and benefiting the pharynx,dispersing lung and reducing Qi,removing blood stasis and dredging collaterals.4.Professor Jiang Baihua’s three characteristics of prescription drugs for the treatment of pulmonary diseases: generous retreatment,combination of warming and clearing,and combination of prevention and treatment.