| The stagnation of Liver-Qi syndrome, which is a familiar syndrome in clinic of TCM, is concomitant with the occurrence and development of many diseases. This research is carried out on liver-qi stagnation syndrome patients by applying methods of behavioral medicine, functional imaging of brain and nerve electrophysiology. By studying the visualized evidence of liver-qi stagnation syndrome patients, this research will provide new methods and ways for the study of relations between liver and brain of TCM.Objective To study the visualized evidence of liver-qi stagnation syndrome patients in personality characteristics, functional imaging of brain and never electrophysiology by applying methods of Minnesota Multiphase Personality Inventory (MMPI), functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) non-linear dynamics study.Methods 1 20 liver-qi stagnation syndrome patients and 20 normal testees paired by sex and age were tested by MMPI. The scores of 13 clinical scales and the section plane of MMPI were acquired and contrastively analyzed. Changes in personality characteristics of the liver-qi stagnation syndrome patients were studied.2 16 liver-qi stagnation syndrome patients and 16 normal testees paired by sex and age were scanned by fMRI. The task of Chinese phrases auditory working memory adopted block-design mode. The scan began from quiet period and the sequence is quiet -baseline - quiet - stimulate- quiet…The scan time of each period was 30 seconds and 360 seconds altogether. Experiments were performed on a Plilips 1.5T MRI scanner. Data analysis was carried out by using SPM based on MATLAB software. Changes in functional imaging of brain of the cognitive function of stagnation syndrome patients were studied.3 15 liver-qi stagnation syndrome patients and 15 normal testees were paired by sex and age. The data of EEG under three states(eyes closed,eyes opened,and mental arithmetic with eyes opened) were analyzed by the parameter of complexity(Cx), correlation dimension(D2), point-wise correlation dimension(PD2) approximate entropy(ApEn). Changes in EEG non-linear dynamics study of the noncognition mission and arithmetic mission of the liver-qi stagnation syndrome patients were studied.Results 1 The study of the liver-qi stagnation syndrome patients by MMPI shows: the 3 validity scales (L, F, K) are in the range of normal value. There is a remarkable difference of 9 clinical scales between the liver-qi stagnation Syndrome group and the normal group in F, Pa, D, Pt, Si, Sc, Hs, Hy, Pd (P<0.05～0.001).The scores of liver-qi stagnation syndrome group were higher than the Chinese normal model in Hs,D,Hy,Pd. The MMPI section plane of liver-qi stagnation group presents the type of 3/1.2 The study of the liver-qi stagnation syndrome patients by fMRI shows: (1) The high activations regional brain of number and area in control group including cingulum gyrus(BA32), left brain: inferior frontal gyrus(BA44/47), middle frontal gyrus (BA8/9), superior parietal lobule(BA10), inferior parietal lobule (BA11), cuneus(BA7); right brain: superior frontal gyrus(BA8), middle frontal gyrus (BA8/9/10),inferior frontal gyrus(BA6/44/47), thalamus; (2) The high activations regional brain of number and area in liver-qi stagnation syndrome group including left brain: inferior frontal gyrus(BA46),superior frontal gyrus(BA8), precentral gyrus(BA6); (3) The decline activations regional brain of number and area in control group including cingulum gyrus(BA30), left brain: precentral gyrus(BA4); right brain: postcentral gyrus(BA40), lingual gyrus (BA29) , superior temporal gyrue(BA20/38), cerebellum. (4) The decline activations regional brain of number and area in liver-qi stagnation syndrome group including left brain: middle frontal gyrus(BA8/9/10/46), superior parietal lobule(BA7), inferior parietal lobule (BA40), cuneus(BA19), thalamus. The number and area of high activations regional brain in control group were more than those in liver-qi stagnation syndrome group, but the working memory decline areas in control group were less than those in liver-qi stagnation syndrome group.3 The EEG non-linear dynamics study of the liver-qi stagnation syndrome patients by fMRI shows: (1) There are statistical differences between the liver-qi stagnation syndrome group and the normal group in condition of eyes closed. (2) There is a statistical difference of PF1-A1,PF2-A2,F3-A1,F4-A2,C3-A1,C4-A2,F7-A1 between the liver-qi stagnation syndrome group and the normal group in condition of eyes opened, The ECG telecom of brain cortex increased in frontal and parietal.(3) There is a statistical difference of P3-A1,O1-A1,T5-A1,T6-A2,T5-A1 between the liver-qi stagnation syndrome group and the normal group in condition of mental arithmetic with eyes opened. (4) Under the three states, the four parameters of the EEG non-linear dynamics in the liver-qi stagnation syndrome patients group were generally higher than those of the normal group. With the increase of stimulated condition, from noncognition mission of eyes closed and eyes opened to cognition mission of mental arithmetic with eyes opened, the statistical difference of lead number was gradually reduced. Conclusions 1 There are some special changes in personality characteristics among the liver-qi stagnation patients such as excessive attention of physical syndrome, decline of social adaptation, depression, anxiety, loneliness, indifference, excessive dependence and demand for others'attention.2 There are changes in cognitive functions among the liver-qi stagnation syndrome patients. The changed functional brain areas of liver-qi stagnation syndrome were confirmed. Therefore, this study offers objective visualized evidence to this syndrome of TCM.3 There are changes in nerve cell discharge among the liver-qi stagnation syndrome patients. The ECG telecom of liver-qi stagnation syndrome group differed from the normal group and the difference gradually reduced from noncognition mission to cognition mission. The EEG non-linear dynamics study objectively and precisely observed the functional changes of brain cortex from noncognition mission to cognition mission.4 The study orientationed the function areas of brain in frontal lobule and parietal lobule. The visualized evidence of impersonality about the stagnation of Liver-Qi syndrome has been obtained. This is the reason which changes in personality characteristics among the liver-qi stagnation patients. |
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