Light Capsule Anti Preliminary Efficacy Study Of Former Female Depression

Objective: Elementarily through the experimental method, discuss the treatment of Chinese herbs for the premenstrual depression state which is made by high estrogen level. Then explore and analyze the mechanism for the effect on 5-HT in the central nervous system which is taken by Chinese herbs.Methods: Firstly, KM mouse aged at 35-45 days were divided into six groups: (1) control group;(2) Estradiol group, (3)Estradiol with Moclobemide group; (4)Estradiol with Zoloft group; (5) Estradio with Jingqing Capsule with little dose group;(6) Estradiol with Jingqing Capsule with great dose group. Through setting the files of estrous cycle individually, injecting estradiol benzoate via subcutaneous injection except control group during the estrous period.At the same time, the rats of the Estradiol with Moclobemide group was given Moclobemide by gavage; Estradiol with Zoloft group, Zoloft; Estradio with Jingqing Capsule with little dose group, Jingqing Capsule with little dose; Estradiol with Jingqing Capsule with great dose group, Jingqing Capsule with great dose .We observed the index of vaginal keratinocyte, the duration of immobility in mouse tail suspension test,and so on. Secondly, 5-HTP induced head-twitches test was used . KMmouse aged at 35-45 days were divided into six groups: (1) physiological saline with 5-HTP group;(2) Estradiol with 5-HTP group, (3)Estradiol and Moclobemide with 5-HTP group; (4)Estradiol and Zoloft with 5-HTP group; (5) Estradiol and Jingqing Capsule with little dose with 5-HTP group;(6) Estradiol and Jingqing Capsule with great dose with 5-HTP group. After administration 5-HTP, head-twitch response was observed. Thirdly, rats aged at 3-4months were divided into five groups: (1) control group;(2) Estradiol group, (3)EstradioI with Moclobemide group; (4)Estradiol with Zoloft group; (5) Estradiol with Jingqing Capsule with great dose group.Serum E₂,P were...