The Jianpiyishenfang Granule In Treating Lung Cancer Associated With Anemia Clinical Research

Cancer-related anemia results from malignant tumor,chemotherapy,radiotherapy and so on.It occurs in high probability,especially for the advanced stage.About 50% to 60% of advanced lung cancer may appear anemia.Not only cancer-related anemia can impair quality of life,but also it can badly influence curative effect and clinical prognosis.Both blood transfusion and recombination human erythropoietin are effective treatments.Nevertheless,their applications are restricted by the short duration,side effects and expensive cost.In traditional chinese medicine(TCM),cancer-related anemia belongs to the categories of"xue xu"(deficiency of blood),"xu lao"(consumptive diseases)and others.Deficiency of spleen ahd kindey is the main causation,according to which,strengthening the spleen,reinforcing the kidney,invigorating qi and nourishing blood is established as therapeutic principle.We accurately assessed the clinical effect of Jianpi Yishen granule in lung cancer patients suffering from cancer-related anemia by prospectively randomized control clinical trial.At the basis of project,60 cases were admitted in two first-grade,first-class Beijing hospitals from when two periods of treatment were finished.They were divided into two groups on principle of minimizing imbalance index in anemia degree,TNM grade and previous chemotherapy cycles.There were 30 patients in each group.Both groups subjected to necessary treatments including chemotherapy,radiotherapy and heteropathy.Only the treated group subjected to Jianpi Yishen granule.There are results following.â‘ The grade of clinical symptoms falled gradually in treated group(P<0.001).20 of them showed significant improvement(66.67%),8 of them had response(26.67%)and the rest 2 cases were futile(6.67%).The response rate was 93.33%.At the same time,the control group made no difference after treatment(P>0.05).6 of them improved significantly(20.00%),9 of them had response(30.00%)and 15 cases were futile(50.00%).The response rate was 50%.It was concluded by multivariate analysis of variance(MANOVA)that the downtrend of grade was curve in two groups.Further more,the treated group descended excessively(P<0.05).Analysed by Wilcoxon nonparametric test,the response rate of clinical symptoms in the treated group remarkably excelled the control group(P<0.001).â‘¡The main symptoms include lack of vitality,lassitude,loss of appetite,abdominal distention,dizziness,tinnitus and dim complexion.The treated group improved prominently on every single symptom(P<0.05).Whereas,the control group do not have obvious change(P>0.05).There was significant difference between them(P<0.01).â‘¢The level of hemoglobin(Hb) keep stable in treated group(P>0.05)when linearly dropping in control group(P<0.05).MANOVA revealed that the change got no statistic significance between them(P>0.05).â‘£Red blood cell volume distribution width(RDW)became larger in two groups.By MANOVA,we knew that...