| According to the TCM theory, the ancient and mordern medical litera- tures and the turtor's clinical experiences , The pathogenesis of apoplexy is profoundly discussed in this paper. The doctrines of "accumulated etiolo- gy","accumulation and deficiency of Vital Qi" and Treatise on "toxic pathogen of apoplexy" are put forward The development of apoplexy is the inevitable results due to extremes of accumulaton and deficiency of vital Qi and accumulation of etiology, and its basic pathogenesis owe toxic pathogen throngh the disease course, attacking the head and the heart by toxic or stagnation in the meridian The syndromes of apoplexy omen are mainly in- duced by heat " toxic and toxic pathogen stagnating in the meridian. on the above and-reatment before disease" , method of eliminating heat to detox- ify ,The prescription of NaoNingKang (NNK) non " sugar granules is de- veloped. 46 cases of apoplexy omen were treated by the granules, and the same amount cases were treated by Asp as the clinical control group. Re- sults showed that the total effective rate of test group is 93.48 % and the control group is 40.6% .The former is far higher than the latter(P <0. 01) . Followed one year, the incidence of apoplexy of test group is 2.17%, Farlowerthan that of the control group which is 13.04%(P |