Clinical Study On Advanced Non-small Cell Lung Cancer With The Pirnciple Of Supplementing Qi And Removing Blood Stasis Combined With Chemotherapy

Objective:Based on the principle of supplementing Qi and removing blood stasis,aged patients with lung cancer were treated with taxotere and cisplatin in combination withShen-qi-fu-zheng injection(SQFZ) and Xue-shuan-tong powder for injection(XST).Furthermore, clinically therapeutic effects were observed and potential mechanism wasdiscussed.Methods:80cases with advanced non-small cell lung cancer (NSCLC) were dividedinto treatment group (40cases) and control group (40cases) at random. Taxotere andcisplatin were given to the control group, while the treatment group was treated withchemotherapy in combination with SQFZ and XST.68cases completed the entire study.The short-term clinical efficacy, symptoms, performance status (PS) score, body weight,markers of blood coagulation, D-dimer(D-D), T cell subgroups, adverse events, time toprogression (TTP) and median survival time (MST) in two groups were compared andanalyzed.Results:Short-term efficacy:The overall effective rate in treatment group (39.5%)was slightly higher than in the control group (26.7%), but there was no significantdifference between two groups (P＞0.05).The incidences of adverse reaction in treatmentgroup were significantly lower than those in the control group (P＜0.05). The performancestatus score, symptomatic improvement and amendments of immune indicators andcoagulation markers in the treatment group were significantly better than in the controlgroup(P＜0.05). The median time to progression in treatment group was155days, whilethat in control group was127days. Although the median time to progress tended to be higher in the treatment group than in control group, the difference between the two groupsdid not reach statistical significance. The median survival time (MST) of treatment groupwas320days, and it was significantly higher than that of control group (P＜0.05).Conclusion:(1) Blood stasis due to Qi deficiency is a main pathogenesis in agedpatients with advanced NSCLC, and chemotherapy in combination with the principle ofsupplementing Qi and removing blood stasis might be helpful to attenuate adverse drugevents, improve clinical symptoms and quality of life, and prolong the survial time.(2)Hypercoagulabale state exists generally in aged patients with advanced NSCLC, andapplication of medicines for promoting blood circulation and removing blood stasis doesnot speed up recurrence and metastasis of lung cancer in our study.