Clinical Observation On The Treatment Of Unknown Cause Recurrent Miscarriage By Tonifying Kidney And Removing Blood Stasis Combined With Acupoint Injection Of Self-blood

Objective:In this study,we observed the clinical effect of kidney-tonifying and blood-stasis removing therapy combined with auto-blood acupoint injection and traditional western medicine on the treatment of unexplained recurrent spontaneous abortion(URSA)patients with kidney deficiency and blood stasis,and explored the idea of combining traditional western medicine with internal and external treatment of traditional Chinese medicine to treat the disease.Methods: 90 patients who met the diagnosis and inclusion criteria of URSA kidney deficiency and blood stasis type were randomly divided into control group,treatment group A and treatment group B.The treatment group B was treated with self-blood acupoint injection pretreatment combined with traditional Chinese medicine for tonifying kidney and removing blood stasis and didrogesterone for fetal protection;Treatment group A was treated with traditional Chinese medicine for tonifying kidney and removing blood stasis combined with traditional western medicine(didroxyprogesterone)for fetal protection;The control group was treated with traditional western medicine to protect the fetus.The treatment group B was treated with self-blood acupoint injection pretreatment 3 months before pregnancy.After confirming pregnancy,the treatment group was treated with traditional and western medicine to protect the fetus until 10 weeks of pregnancy.The treatment group A and the control group were treated with traditional and western medicine to protect the fetus and traditional western medicine to protect the fetus until 10 weeks of pregnancy from the time of confirming pregnancy.Finally,the clinical observation results were obtained by comparing the difference of the pregnancy success rate of the three groups of patients at 12 weeks of gestation,TCM syndrome score,TCM syndrome efficacy,serum progesterone andβ-HCG levels,gestational sac diameter and embryo length,and clinical comprehensive efficacy.Results:1.A total of 90 patients were included in this study,all of which met the criteria for diagnosis and inclusion.During the treatment,1 patient fell off and 1 patient was removed from the control group,1 patient fell off and2 patients were removed from the treatment group A,2 patients fell off and1 patient was removed from the treatment group B.Finally,27 patients in treatment group A and treatment group B completed clinical observation,while28 patients in control group completed clinical observation.2.There was no significant difference in the basic information(age,duration of disease,number of previous miscarriages,maximum number of previous miscarriages,and weeks of first diagnosis of second pregnancy)and TCM syndrome score before treatment among the three groups(P>0.05).The three groups were comparable in efficacy.3.After treatment,the TCM syndrome scores of the three groups were significantly lower than those before treatment(P<0.05),and the difference was statistically significant between the treatment group B and the treatment group A and the control group(P<0.05).4.The total effective rate of TCM syndrome in treatment group B was 96.30%,the total effective rate of clinical comprehensive effect in treatment group A was 88.89%,and the total effective rate of clinical comprehensive effect in control group was 60.71%.The difference was statistically significant(P<0.05).5.After treatment,the progesterone level was compared within the group: the P water level of the three groups increased with the increase of gestational age on average.The treatment group B and the treatment group A were compared during the period of 6,8 and 10 weeks of gestation,respectively.The difference was statistically significant between 6 weeks of gestation<8 weeks of gestation<10 weeks of gestation(P<0.05);In the control group,there was no statistically significant difference between 6 weeks of pregnancy and 8weeks of pregnancy(P>0.05).The difference was statistically significant between 6 weeks of pregnancy and 10 weeks of pregnancy(P<0.05).The difference was statistically significant between 8 weeks of pregnancy and 10 weeks of pregnancy(P<0.05).Comparison of progesterone levels between groups: treatment group B>treatment group A(P>0.05)at the 6th week of pregnancy,the difference was not statistically significant;treatment group A>control group(P>0.05),the difference was not statistically significant;treatment group B>control group(P<0.05),the difference was statistically significant;The difference between treatment group B>treatment group A>control group at 8 weeks and 10 weeks of pregnancy was statistically significant(P<0.05).6.Intra-group comparison of β-HCG level: After treatment,the β-HCG level of patients in the three groups increased with the increase of gestational age.The three groups were compared during the period of 6,8 and 10 weeks of gestation,and the difference was statistically significant(P<0.05).Comparison of β-HCG levels between groups: β-HCG levels at 6 weeks,8 weeks and 10 weeks of pregnancy were significantly higher in treatment group B>treatment group A>control group(P<0.05).7.During the treatment,observe the gestational sac diameter and embryo length of the three groups at the same time(6,8 and 10 weeks gestation): treatment group B>treatment group A>control group,the difference was statistically significant(P<0.05).8.The pregnancy success rate at 12 weeks of pregnancy in treatment group B was 92.59%,the pregnancy success rate at 12 weeks of pregnancy in treatment group A was 66.67%,and the pregnancy success rate at 12 weeks of pregnancy in control group was 42.86%.The difference between treatment group B and treatment group A was not statistically significant(P>0.017);Treatment group B>control group(P<0.017),the difference was statistically significant;There was no significant difference between treatment group A and control group(P>0.017).9.The total effective rate of clinical comprehensive efficacy in treatment group B was 88.89%,the total effective rate of clinical comprehensive efficacy in treatment group A was 59.26%,the total effective rate of clinical comprehensive efficacy in control group was 25%,and the difference was statistically significant(P<0.05)Conclusion:The combination of auto-blood acupoint injection pretreatment,traditional Chinese medicine tonifying kidney and removing blood stasis,and traditional western medicine of didroxyprogesterone in the treatment of URSA patients with kidney deficiency and blood stasis has achieved satisfactory clinical results.The treatment of URSA with Chinese and western medicine combined with self-blood acupoint injection preconditioning can better improve clinical symptoms;It can effectively improve the progesterone level in early pregnancy,promote the growth of pregnancy sac and embryo,facilitate the growth and development of embryo,and improve the success rate of pregnancy at 12 weeks of pregnancy;This program has significantly improved the clinical comprehensive efficacy.