| Purpose:To discuss the understanding of traditional Chinese medicine about 2 diabetes with osteoporosis, using the therapy of renal-vital-reinforce and Bone-vital-strong Prescription to treat type 2 diabetes with osteoporosis.To observe the therapeutic efficacy of this prescription in treating type 2 diabetes with osteoporosis liver-Kiney deficiency symptoms by the indexes such as clinlcal symptom, hormone, cytokine, bone mineral density.Then evaluate its curative effect and safety, so as to guide itsclinical applicationMethods:A randomized, controlled trial was conducted.The patients of type 2 diabetes with osteoporosis were randomly classified into two groups according to 1:1pair matched.On the basic of normal treatment and western medicine, the patients of treated group were treated by Chinese medicine while the patients of controlled group were treated by Calcium Carbonate and Vitamin D3 Chewable Tabletas. observing for 3 month and four weeks made up of a course of treatment.The observed indexes included curative effect indexes, such as clinic symptoms, blood glucose, HbAlc, serum calcium and phosphate, estradiol, testosterone, NO, IL-6, urinary calcium, BMD and so on.The complete data carries on statistics analysis by the SPSS16.0 statistics software.Results:The diagnosis and included type 2 diabetic patients with 50 cases.25 cases of treated group, while 25 cases of controlled group. Prior treatment, the gender, age, course of disease of the two groups patients had no differeces.1.Symptoms and signs improvement:the treated group after treatment had a significant improvement. The symptoms improvement of the treated group was better than the controlled group (P<0.01).2.Blood glucose:the FBG, PBG of treated group and controlled group were significantly lower(P<0.01); After treatment, the FBG of the treated group had a significantly difference than controlled group(P<0.01).The PBG of treated group also had a difference than controlled group (P<0.05), The HbAlc of treated group also had a difference than controlled group (P<0.05).3. bone mineral density:After treatment, the BMD of the treated group were significantly higher than controlled group(P<0.01). while the controlled group had no statistical significance(P>0.05).the BMD of the treated group had a difference than controlled group(P<0.05).4.calcium and phosphate:Serum calcium of the two groups were lower, but had no statistical significance(P>0.05).Serum phosphate of the two groups were higher, but had no statistical significance.Serum calcium and phosphate of the controlled group had no statistical significance(P>0.05).After treatment, the urinary calcium and phosphate of the treated group were visibly lower, had a significantly difference than controlled group(P<0.01).The urinary calcium and phosphate of the treated group had a difference than controlled group(P<0.05).5.hormone:In the male sufferer, after treatment, the E2 of the treated group was visibly lower, had a significantly difference than controlled group(P <0.05), the T of the treated group was visibly higher, had a significantly difference than controlled group(P<0.01).The improvement of E2 of the treated group had a difference than controlled group(P<0.05).the improvement of T of the treated group was better than the controlled group, but had no statistical significance(P>0.05).In the female sufferer, the E2 of the treated group was visibly higher(P<0.01), the Twas visibly lower(P<0.01).The improvement of E2 of the treated group was better than the controlled group(P<0.05), the improvement of T of the treated group was better than the controlled group, but had no statistical significance(P>0.05).6.NO,IL-6:After treatment, the NO of the treated group were significantly higher(P<0.01), and had a significantly difference than controlled group(P <0.01).The IL-6 of the treated group were also significantly improved(P<0.01), and had a significantly difference than controlled group(P<0.05).7.safety index:The routine blood/urine/feces test, and the liver and kidney function tests of treated group were within the normal range. two groups had no unhealthy response.Conclusion:Through the preliminary clinical study, Bone-vital-strong Prescription has sure curative effected in treating type 2 diabetes with osteoporosis liver-Kiney deficiency symptoms. From the angle of western medicine, it can reduce blood sugar and HbAlc, improve BMD, decrease the exhaust of urinary calcium, and adjust hormone.And, most important, be safe and effective.It is worth studying deeply and developing further.Remarkable results have been achieved by Bone-vital-strong Prescription that reducing blood and improve BMD.But because of my ability and conditions limited as a overseas student, there were small number of cases and simple observational items in this study. And further inestigations is required. |
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