| Purpose:To explore the understanding of type 2 diabetic osteoporosis in traditional Chinese medicine,and to evaluate the effect of BushenTianjingHuayu Decoction on type 2 diabetic osteoporosis.The effect of treatment,especially on clinical symptoms,bone mineral density,cytokines and other aspects of the treatment,and to evaluate its clinical efficacy and safety,to provide an objective basis for clinical application.Methods:Patients with type 2 diabetic osteoporosis were randomly divided into control group and treatment group according to the principle of 1:1 control.In the basic treatment and conventional hypoglycemic treatment of traditional Chinese medicine on the basis of the control group given calcium Erqi D tablets 600mg,1 day,the treatment group to give a day of traditional Chinese medicine decoction,divided into two times a day later.To 4 weeks for a course of treatment,observed 3 courses.The levels of serum calcium,phosphorus,nitric oxide,interleukin-6,urinary calcium and bone mineral density were measured before and after treatment,and the changes of clinical symptoms and signs were evaluated before and after treatment.All the data were analyzed by SPSS22.0 statistical software.Results:60 cases of type 2 diabetic osteoporosis were randomly divided into two groups,the treatment group of 30 cases,the control group of 30 cases,the two groups before treatment,gender,age,duration and other baseline data were statistically no significant difference,Comparable.The results are as follows:①the improvement of symptoms and signs:the treatment group after treatment symptoms were significantly improved,the treatment group of traditional Chinese medicine symptoms improved significantly better than the control group(P<0.01).② Hypoglycemic effect:the treatment group and the control group of patients with fasting blood glucose,postprandial blood glucose were significantly reduced,compared with before treatment were significantly different(P<0.01);treatment group after treatment fasting blood glucose improvement compared with the control group were significantly different(P<0.01).The improvement of postprandial blood glucose in the treatment group was different from that in the control group(P<0.05).The improvement of glycosylated hemoglobin in the treatment group was different from that in the control group(P<0.05).③ Increase bone density:After treatment,the BMD of the treated group were significantly higher than controlled group(P<0.01).while the controlled group had no statistical significance(P>0.05).the BMD of the treated group had a difference than controlled group(P<0.05).si5calcium and phosphate:Serum calcium of the two groups were lower,but had no statistical significance(P>0.05).Serum phosphate of the two groups were higher,but had no statistical significance.Serum calcium and phosphate of the controlled group had no statistical significance(P>0.05).After treatment,the urinary calcium and phosphate of the treated group were visibly lower,had a significantly difference than controlled group(P<0.01).The urinary calcium and phosphate of the treated group had a difference than controlled group(P<0.05).⑤NO、IL-6:After treatment,the NO of the treated group were significantly higher(P<0.01),and had a significantly difference than controlled group(P<0.01).The IL-6 of the treated group were also significantly improved(P<0.01),and had a significantly difference than controlled group(P<0.05).⑥Hemorheological parameters:The whole blood viscosity(high and low and middle shearing),erythrocyte agglutination,RBC aggregation and erythrocyte rigidity indexes were significantly decreased(P<0.05,P<0.01).After treatment,the blood viscosity of middle shear rate and RBC aggregation indexes decreased more significant and had statistically significant difference than controlled group(P<0.05).⑦safety indicators:the treatment group of patients with blood,urine,fecal routine and liver and kidney function tests are in the normal range.There were no adverse reactions in both groups.Conclusion:From the preliminary clinical study,BushenTianj ingHuayu Decoction treatment of type 2 diabetes osteoporosis liver and kidney deficiency syndrome,can significantly improve the clinical symptoms of patients;in Western medicine indicators,can reduce blood sugar,glycosylated hemoglobin,improve bone mineral density,Reduce urinary calcium excretion,and no liver and kidney function damage,the treatment of the disease safe,effective,has a wide range of applications.BushenTianj ingHuayu Decoction has achieved control of diabetes and improve bone mineral density of significant treatment. |
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