Clinical Study On Laparoscopic Assisted Mini-incision Supracervical Hysterectomy

Objective To evaluate the feasibility of laparoscopic assisted mini-incision supracervical hysterectomy and its effect on systemic stress and cell-immediated immunity. Methods Compare surgery related parameters and quality-of-life outcomes in three groups receiving laparoscopic-assisted mini-incision supracervical hysterectomy, laparoscopic supracervical hysterectomy, or open hysterectomy, respectively. Peripheral blood samples before and after surgery were evaluated the levels of IL-1β, IL-6, IL-10, TNFα, hs-CRP with ELISA and the proportions of CD4~+, CD8~+, CD31~+ lymphocyte with Flow Cytometry. Results Laparoscopic-assisted mini-incision supracervical hysterectomy resulted in better surgical related parameters and quality-of-life outcomes compared with open hysterectomy, but similarly with laparoscopic supracervical hysterectomy. Less changes of serum level of IL-1β, IL-6, IL-10, TNFα, hs-CRP were found in Laparoscopic-assisted group and Laparoscopic group than those in open group. The changes of proportion of CD4~+, CD31~+ lymphocyte in Laparoscopic-assisted group and Laparoscopic group were less than those in open group after surgery.Conclusion Laparoscopic-assisted mini-incision supracervical hysterectomy was minimal access surgery, with less effect on systemic stress and cell-immediated immunity.