Antifatigue Effects Of Salidroside On Mice And Its Mechanism

The antifatigue effects of salidroside and its dose —effect relation on the swimming performance of the mice were investigated, and an optimum dosage of salidroside for antifatigue effect was determined. Then we studied the antifatigue mechanism of salidroside from several aspects and investigated the molecular biology mechanism . The results showed that Salidrosid had a significant antifatigue effect on mice and had its optimum dose. Several aspects involve in the antifatigue effection of salidroside. Salidroside can induce antioxidase activity and reduce the damage of cardiac muscle and skeletal muscle after long time endurance exercise;salidroside have an effect on the amino acid metabolism of brain and can prevent the decline of NO by improving NOS activity after long time endurance exercise;Salidroside has a significant effect on glucose ,fat and amino acid metabolism and can improve the aerobic capacity. Salidroside may improve oxidize metabolic capability andantifatigue capability of the skeletal muscle by improving the expression of PGC-1α ,PPARα and mtTFA protein in skeletal muscle.