Theory Probing And Experiment Study Of The Correlativity Between Lung Aging

Object: Probing the close relationship between lung aging under the direction of TCM theory , then through experiment study , to confirm the mechanism of the correlativity , so as to offer warranty of theory and experiment for postpone the aging from lung .The text was divided into two parts: theory probing and experiment study .Theory probing : Lung aging have close relationship through the study of ancient words, the lung dominates Qi , characterized Qi by dispersing outward and downward . associated with the skin and hair . 1. The essence and Qi of lung is the main material basic which maintain the function of skin, the lung controls respiration and smoothes the pores so as to nourish the skin, the lung characterizes Qi by dispersing outward and dispersing body fluid so as to nourish the skin, many large blood vessels converge in the lung , smoothing Qi and blood so as to nourish the skin, the lung is associated with skin and has an exterior and interior relationship with large intestine, exhaling stale gas so as to clean skin. 2.The deficiency of the essence and Qi of lung is the main mechanism of aging, the lung can't control respiration and smooth thepores so that it can't nourish the skin any more, the lung can't characterizes Qi by dispersing outward and dispersing body fluid so that it can't nourish skin any more . many large blood vessels can't converge in the lung , and it can't smooth Qi and blood so that it can't nourish skin any more, the lung can't exhale stale gas so that it can't clean skin any more. 3.Regulating and reinforcing the essence and Qi of lung is the important theorem of postponing the skin aging, the essence and Qi of lung including two parts: Yang-Qi and Yin-essence of lung. The regulating and reinforcing the two parts can postpone the skin aging through the ways as follows: reinforcing the lung-Qi so as to nourish skin; smoothing the lung-Qi so as to smooth Qi and blood; dispersing stale gas outward and downward so as to clean skin.Experiment studyMethods: The rats were randomly divided into five groups: normal control group; model group; Vitamin E-C group; BFT therapying low dose group and BFT therapying large dose group.The aging rat model of lung deficiency syndrome was induced by subcutaneous injection of 12.5% D-Galactose on the back near neck 0.16ml daily for four weeks. We observed MDA, SOD.Results: 1.BFT groups all can increase the contents of SOD and decrease the contents of MDA. Especially the preventing large dose group,There was a very significant changes (P<0.01). 2.The contents ofalveolar mac-rophage was increased obviously in model group, BFT can decreased it, There were very significant changes (P<0.01). 3.There were obviously apoptosis in model group, BFT can improve the ultrastructure pathological changes of lung and skin. 4. The expression of PCD was obviously decrease in model group than in normal control group(P<0.01), BFT can increase the expression of significantly(P<0.01).Conclusion: Three were mang changes in model group, such as: the decrease of SOD,the increase of MDA, ultrastructure pathological changes etc. It means the aging model of lung deficiency was successfully founded. BFT can decrease the contents of free radical,restrain apoptosis, improve immune function, Though these it can postpone aging.