Study On The Correlation Between TCM Syndromes Of Diabetic Foot And Physical And Chemical Indicators And Cardiovascular Disease

ObjectiveThrough the collection of clinical data and TCM patterns of diabetic foot patients,the correlation between the TCM patterns of diabetic foot patients and physical and chemical indices and cardiovascular lesions was investigated,reflecting the TCM etiological and pathological characteristics of diabetic foot from the side,exploring whether physical and chemical indices can provide a reference basis for TCM classification of diabetic foot,and providing an objective basis for the prevention and treatment of diabetic foot and cardiovascular complications by combining Chinese and Western medicine,so as to This study will provide an objective basis for the prevention and treatment of diabetic foot and cardiovascular comorbidities by combining Chinese and Western medicine.MethodsOne hundred and eighty-five patients with DF who met the inclusion criteria were selected and their basic data,physical and chemical examinations(blood glucose,blood coagulation,blood lipids,etc.)and comorbidities were collected and re-diagnosed and staged.The correlation between the physical and chemical parameters and the occurrence of cardiovascular disease in patients with different types of DF was investigated using SPSS25.0.Results1.There were significantly more males than females with diabetic foot,142 males and 43 females,and more males than females in all age groups.10 patients aged 50 years and below accounted for only 5%of the total,38 patients aged 51 to 60 years accounted for 21%of the total,65 patients aged 61 to 70 years accounted for 35%of the total,and the maximum number of patients aged 70 years and above was 108,accounting for 39%.This accounted for 39%of the total.2.87 patients(47%of the total)had a history of smoking and 56 patients(30%of the total)had a history of alcohol consumption.3.The number of patients with diabetes for less than 10 years was low at 37 out of 185,accounting for 20%of the total.63 patients(34.05%)had diabetes for between 10 and 20 years,and the highest number of patients(45.59%)had diabetes for more than 20 years.4.Among the cases collected,43(23%)had the highest number of patients with Damp-Heat-Toxic syndrome,followed by Blood Vessel Stasis syndrome,which was similar to Damp-Heat-Toxic syndrome,with 41(22%);37(20%)had Heat-Toxic Yin Injury syndrome;35(19%)had Qi-Yin Deficiency syndrome;and 29(16%)had Cold-Dampness Blocking Complex syndrome.5.The fasting blood glucose level and glycated haemoglobin were the highest among the five groups in the Damp-Heat-Toxic group,while the fasting blood glucose level in the Heat-Toxic-Yin group was the lowest,but still higher than normal.There was a statistically significant difference between the fasting blood glucose level and glycated haemoglobin level in the Damp-Heat and Poisonous Yin group(P<0.05),and there was a statistically significant difference between the glycated haemoglobin level in the Damp-Heat and Poisonous Yin group and the Qi-Yin two deficiency group and the Blood Vessel Stasis group(P<0.01),and there was a statistically significant difference between the Blood Vessel Stasis group and the Cold-Dampness Blocking and Poisonous Yin group(P<0.05).6.CRP level was the highest in Damp-Heat-Toxic evidence,with significant differences compared with other evidence(P<0.01).The CRP level of heat toxin wounding yin evidence was in the second place,and the CRP level of patients with cold dampness blocking the ligament evidence was the lowest.7.TC,TG and LDL-C levels were in the normal range and HDL-C levels were below normal in all DF patients.TC,TG,LDL-C and HDL-C were all highest in the cold-damp blockage group and lowest in the damp-heat toxicity group.There was a statistically significant difference between TC in the cold-damp blocking group and all other groups(P<0.01);LDL-C in the cold-damp blocking group was statistically different from that in the damp-heat-toxic group(P<0.01),and statistically different from that in the heat-toxic-injurious-yin group(P<0.05);HDL-C in the cold-damp blocking group was statistically different from that in the damp-heat-toxic group(P<0.05);there was no statistical difference in TG levels between the groups(P>0.05).There was no statistical difference in TG levels between the groups(P>0.05).8.The UA level was the lowest in the cold-damp blockage group and the highest in the qi-yin deficiency group,with a statistical difference between the two groups(P<0.05).9.Patients with DF foot can be combined with a variety of complications.The top five diseases with the highest incidence were diabetic peripheral vasculopathy,diabetic peripheral neuropathy,hypertension,cardiovascular disease and cerebral infarction.Diabetic peripheral vasculopathy had the highest prevalence(96.21%),followed by diabetic peripheral neuropathy(70.27%),hypertension(70.27%)cardiovascular disease(60%),hyperlipidaemia(45.95%)and cerebral infarction(44.32%)respectively.10.The main combined cardiovascular diseases in DF patients were coronary atherosclerotic heart disease and heart failure,of which 74.77%were combined with coronary atherosclerotic heart disease,8.11%were combined with heart failure alone,and 17.12%were combined with both coronary heart disease and heart failure.11.Of the 51 patients with 0-3 comorbidities,14(27.50%)had the most damp-heat toxicity,10(19.61%)had the second most cold-damp obstruction,8(15.67%)had blood stasis,7(13.73%)had qi-yin deficiency,and 1(1.96%)had the least qi-yin deficiency.There were 94 cases with 4-6 complications,which were more evenly distributed,including 21 cases(22.34%)of damp-heat toxicity,20 cases(21.28%)of blood stasis,19 cases(20.21%)of heat toxicity injury to yin,and 17 cases(18.09%each)of both cold-dampness blockage and deficiency of qi and yin.The number of comorbidities was greater than 6 in 40 patients,with blood stasis in 13 cases(32.50%),qi-yin deficiency in 11 cases(27.50%),damp-heat toxicity in 8 cases(20.00%),heat toxicity injuring yin(15.00%),and cold-dampness blocking ligaments in 2 cases(5.00%).12.In this study,there were 111 patients with DF combined with cardiovascular disease,including 26 cases(74.29%)with Qi and Yin deficiency,18 cases(62.07%)with cold-dampness blocking the ligament,19 cases(51.35%)with heat and toxicity injuring Yin,17 cases(39.53%)with dampness-heat and toxicity,and 13 cases(30.23%)with blood stasis,P<0.01,suggesting a statistically significant difference.Conclusion1.The occurrence of diabetic foot is positively and closely related to age and the duration of diabetes.The older the patient is,the higher the incidence of diabetic foot,and the longer the duration of the disease,the higher the incidence of diabetic foot.2.The most widespread type of diabetic foot is damp-heat-toxic,followed by blood stasis,heat-toxic Yin injury,Qi-Yin deficiency and cold-damp blockage.3.Patients with Damp-Heat and Poisonous Evidence were characterized by elevated FBG and HbAlc;CRP levels were significantly elevated in this group of patients,which was associated with inflammatory response and could be considered as a reference for clinical diagnosis of Damp-Heat and Poisonous Evidence.PT is prolonged and FIB is elevated in patients with blood vessel stasis.TC,TG,LDL-C and HDL-C are all elevated in patients with cold-damp blockage evidence.4.Patients with diabetic foot can be combined with a variety of diseases,and the prevalence of cardiovascular disease is as high as 50.27%,with the highest probability of coronary heart disease in patients with Qi and Yin deficiency evidence.