| Purpose:By means of collecting and evaluating platelet-related laboratory indicators,platelet-lymphocyte ratio(PLR),bilirubin level and Hamilton Depression Scale scores in patients with angina pectoris after coronary revascularization,preliminary study the correlation between depression and platelet,PLR and bilirubin levels in patients with angina pectoris after coronary revascularization.To analyze the distribution of TCM syndromes in patients with angina pectoris after coronary revascularization,and to explore the correlations between platelet,PLR,bilirubin levels,and the Hamilton Depression Scale score with TCM syndrome distribution,which is helpful for TCM in the diagnosis and treatment of this disease.Provide ideas and basis to play a good role.Material and method:A cross-sectional study was used to collect data on patients with angina pectoris after coronary revascularization who visited the First Department of Cardiology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine and the Department of Cardiology,Liaoning Provincial People’s Hospital from December 2020 to September 2021(including General information,physical and chemical examination,depression scale score and TCM syndrome classification).They were divided into a depressed group and a non-depressed group according to the scores of the Hamilton Depression Scale(17-item version).Excel and SPSS22.0 were used to organize and analyze the data,the mean± standard deviation was used to describe the measurement data,and the independent sample t test was used for statistical inference;the frequency and composition ratio were used to describe the count data,and the chi-square test was used for statistical inference.Logistic regression analysis was used to screen the risk factors of angina depressive disorder after coronary revascularization,and Spearman rank correlation was used to analyze the correlation between various biochemical indicators,depression score and syndrome distribution.The test level α was set at 0.05,the difference was statistically significant when P<0.05,and the difference was significant when P<0.01.This study originated from the pilot project of clinical collaboration between Chinese and Western medicine for major and difficult diseases of the State Administration of Traditional Chinese Medicine(disease name: angina pectoris after coronary revascularization,lead unit: Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,no number),and has passed the ethical review(review Approval number: 2019034FS(KT)-016-02,Ethics Committee of Affiliated Hospital of Liaoning University of Traditional Chinese Medicine).Results:1.A total of 100 patients with angina pectoris after coronary revascularization were collected in this study,of which 3 were dropped or excluded,and 97 were finally included,including46 in the depression group and 51 in the non-depressed group.Compared with the non-depressed group,there was no significant difference in age and gender between the depression group and the non-depressed group(P>0.05).2.The results of the study showed that there were significant differences in platelet count(PLT),platelet volume(PCT),PLR,total bilirubin(TBIL),and indirect bilirubin(IBIL)levels between the depressed group and the non-depressed group(P < 0.01),lymphocyte count(TLC),direct bilirubin(DBIL)levels were statistically different(P < 0.05).There was no significant difference in platelet distribution width(PDW)and mean platelet volume(MPV)between the two groups(P>0.05).3.Logistic regression analysis showed that PLR and TBIL were the influencing factors of depression in patients with angina pectoris after coronary revascularization(P<0.01).Among them,Exp(B)>1 of PLR is a risk factor;Exp(B)<1 of TBIL is a protective factor.4.The results of Spearman correlation analysis showed that the levels of PLR(P<0.01),PLT(P < 0.05),and PCT(P < 0.05)were positively correlated with the occurrence of depression;lymphocyte count,TBIL,DBIL,and IBIL levels were associated with depression The occurrence of emotion was significantly negatively correlated(P<0.01).PDW,MPV,gender,age were not correlated with the occurrence of depression(P>0.05).5.Among the included patients,22 cases(22.68%)of Qi stagnation and phlegm stagnation syndrome,22 cases(22.68%)of Qi stagnation and blood stasis syndrome,and 20 cases(20.62%)of Qi stagnation and fire syndrome accounted for the main distribution.The constituent ratios were 12 cases(12.37%)of heart and gallbladder qi deficiency syndrome,11cases(11.35%)of heart and spleen deficiency syndrome,5 cases(5.15%)of yin deficiency and liver stagnation syndrome,and 5 cases(5.15%)of liver and gallbladder damp-heat syndrome.Among them,the depression group had the highest proportion of 14 cases(30.43%)with the syndrome of qi stagnation and blood stasis,and the non-depression group had the highest proportion of 13 cases(25.49%)with the syndrome of qi stagnation and blood stasis and 12 cases(23.53%)with the syndrome of qi stagnation and phlegm stagnation.6.The results of Spearman correlation analysis showed that PLT level was significantly positively correlated with Qi stagnation and blood stasis syndrome(P<0.01),PDW level was significantly positively correlated with Yin deficiency and liver stagnation syndrome,and significantly negatively correlated with Qi stagnation and phlegm stagnation syndrome(P<0.01),MPV level was significantly positively correlated with Qi stagnation and phlegm stagnation syndrome(P<0.01),PCT level was negatively correlated with Yin deficiency and liver stagnation syndrome(P<0.05),lymphocyte count was associated with Qi stagnation and blood stasis syndrome Positive correlation,negative correlation with Qi stagnation transforming into fire syndrome(P < 0.05),PLR level was positively correlated with Qi stagnation transforming into fire syndrome(P < 0.05),DBIL level was negatively correlated with heart and gallbladder Qi deficiency syndrome(P < 0.05),Hamilton Depression scale score was positively correlated with Qi stagnation transforming into fire syndrome(P<0.05).In addition,gender(P < 0.01)and age(P < 0.05)differences were closely related to the occurrence of heart and gallbladder qi deficiency syndrome.Conclusion:1.After coronary revascularization,there are differences in the levels of PLT,PCT,TLC,PLR,TBIL,IBIL,and DBIL between patients with angina pectoris with depression and those without depression.2.PLR is a risk factor for depression in patients with angina pectoris after coronary revascularization,and TBIL is a protective factor.3.The levels of PLR,PLT and PCT in patients with angina pectoris after coronary revascularization were positively correlated with the occurrence of depression;lymphocyte count,TBIL,DBIL and IBIL levels were significantly negatively correlated with the occurrence of depression.PDW,MPV,gender,age were not associated with depression.4.The patients with angina pectoris after coronary revascularization have the syndrome of stagnation of phlegm and stagnation of qi,syndrome of stagnation of qi and blood stasis,and syndrome of qi stagnation transforming into fire.According to the classification,the main syndrome types of patients without depression are Qi stagnation and blood stasis syndrome and Qi stagnation and phlegm depression syndrome.5.Laboratory indicators of patients with angina pectoris after coronary revascularization are related to TCM syndrome differentiation: PLT and TLC levels are positively correlated with the occurrence of Qi stagnation and blood stasis syndrome;MPV level is positively correlated with the occurrence of Qi stagnation and phlegm stagnation syndrome.Phlegm stagnation syndrome was negatively correlated;PDW level was positively correlated with the occurrence of yin deficiency and liver stagnation syndrome,and PCT was negatively correlated with yin deficiency and liver stagnation syndrome;PLR level was positively correlated with the occurrence of qi stagnation and fire syndrome,and TLC was associated with qi stagnation and qi stagnation.Fire syndrome was negatively correlated;DBIL level was negatively correlated with the occurrence of heart and gallbladder qi deficiency syndrome.In addition,the score level of Hamilton Depression Scale was positively correlated with the occurrence of Qi stagnation and fire syndrome. |
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