| Objective(1)To preliminarily investigate the correlation and difference between non-calcified plaques with different degrees of coronary artery stenosis or different CT values and pericoronary fat attenuation index(FAI)and some clinical metabolic parameters;(2)To analyze the difference between some morphological parameters of non-calcified plaques and periplaque FAI in significant and insignificant coronary artery luminal stenosis;(3)To analyze the relationship between high risk group of FAI(FAI≥-70.1 HU)and clinical factors and non-calcified plaque parameters.Methods The CT angiography images and clinical data of 269 hospitalized patients with suspected coronary heart disease were retrospectively collected and divided into four groups according to the degree of luminal stenosis,including 60 patients in the normal group,103 patients in the mild group,63 patients in the moderate group and 43 patients in the severe group(only non-calcified plaques were present in the coronary arteries of the lesion group).The CT value,long diameter and short diameter of non-calcified plaque were measured.They were divided into three groups according to the CT attenuation value of plaques,including 21 patients in the low-attenuation group(CT value ≤ 30 HU),84 patients in the medium-attenuation group(30<CT value≤50 HU),and 104 patients in the high-attenuation group(50<CT value ≤ 120 HU).They were also divided into 106 patients with significant stenosis(≥ 50% stenosis)and 103 patients with nonsignificant stenosis(< 50%stenosis)according to whether coronary luminal stenosis caused by non-calcified plaques was clinically significant.According to whether FAI≥-70.1 HU,86 patients were divided into FAI high-risk group(FAI≥-70.1 HU)and 183 patients into FAI low-risk group(FAI <-70.1 HU).Pericoronary adipose tissue was extracted and corresponding FAI values were obtained on digital coronary CT angiography image analysis software.To analyze the correlation between coronary artery non-calcified plaque and pericoronary fat measurement under different morphological parameters;The correlation between coronary non-calcified plaques under different morphological parameters and pericoronary fat measurements was analyzed;the differences in gender,age,plaque CT value,plaque diameter and clinical metabolic factors between the high-risk and low-risk groups of FAI were analyzed.Results There were significant differences in sex,age,systolic blood pressure and FAI between the normal coronary artery group and the diseased group(P<0.05).The FAI value in the diseased group was significantly higher than that in the normal group.The increase of luminal stenosis was positively correlated with the short diameter of non-calcified plaques(Rs=0.543,P<0.05),FAI value(Rs=0.534,P<0.05)and systolic blood pressure(Rs=0.156,P<0.05),and negatively correlated with plaque CT value(Rs=-0.430,P<0.05).There was no significant correlation between different degrees of coronary artery stenosis and diastolic blood pressure,total cholesterol,triglyceride,low-density lipoprotein,high-density lipoprotein,uric acid,and fasting blood glucose.There were significant differences in FAI values between non-calcified plaques with different degrees of stenosis(P <0.05),and there were significant differences in FAI values between the mild group and the moderate and severe groups(P < 0.05),but there was no significant difference in FAI values between the moderate and severe groups(P>0.05).There were significant differences in FAI values between non-calcified plaques with different CT attenuation values(P< 0.05),and there were significant differences in FAI values between the low-attenuation group and the medium and high attenuation groups(P<0.05),but there was no significant difference in FAI values between the medium attenuation group and the high attenuation group(P>0.05).There was no gender difference in FAI value and the degree of coronary luminal stenosis between the significant stenosis group and the non-significant stenosis group(P > 0.05).There were significant differences in plaque short diameter,plaque CT value and FAI value around the plaque between the two groups(P<0.05).The critical value of FAI value between the two groups was-69.5 HU.There was no significant difference in age and plaque long diameter between the two groups(P>0.05).Men in the high-risk group of coronary FAI accounted for a higher proportion,plaque CT values in the high-risk group of FAI were lower than those in the low-risk group of FAI(P<0.05),plaque short diameter in the high-risk group of FAI was higher than that in the low-risk group of FAI(P<0.05),and plaque short diameter ROC area under the curve(AUC)was 0.659 [95%confidence interval(CI)0.583 ～ 0.734].Conclusion 1.the CT attenuation value and the degree of luminal stenosis of non-calcified coronary plaques were different,and the FAI value of fat around the coronary arteries was different.With the increase of luminal stenosis or the decrease of plaque CT attenuation,FAI showed an increasing trend,and the risk of acute coronary syndrome was higher.2.the FAI caused by non-calcified coronary plaques was higher in the significant stenosis group(≥ 50% stenosis)than in the non-significant stenosis group,that is,the risk was higher in the significant stenosis group.3.men in the high-risk group of coronary FAI(FAI≥-70.1 HU)accounted for a relatively high proportion,with low plaque CT values,larger plaque short diameters,and higher risk. |
