| Objectives:To explore the effects of thyroid function(THS,FT3,TT3,FT4,TT4)and antibodies(TMAb,TGAb)on the clinical features of Guillain-Barre syndrome,and to explore the effects on the prognosis of Guillain-Barre syndrome.Methods:The clinical data of 81 patients diagnosed as GBS(46 cases)/CIDP(35 cases)admitted to the Department of Neurology of the First Affiliated Hospital of Kunming Medical University from August 2019 to January 2021 and 160 mild patients admitted to the department during the same period were retrospectively collected and followed up.Statistical methods were used to compare the demographic and clinical characteristics with the differences in thyroid function and antibodies.GBS/CIDP patients were divided into thyroid antibody positive group and thyroid antibody negative group according to whether thyroid functional antibody was positive.Statistical methods were used to compare the correlation of clinical characteristics,demography,auxiliary examination,treatment and prognosis.Results:1.TMAb/TGAb(+)rates were higher in the GBS/CIDP group(n=81)than in the control group(n=160)(32.1% VS 19.4%,P=0.028).In the GBS group(n=46),FT4 levels were 13.00±3.52 pg/m L VS 12.45±1.76 pg/m L,P=0.030,and TT4 levels were79.89±23.40 ng/m L VS 74.91±14.63 ng/m L.P=0.035)was significantly higher than that of control group.TMAb/TGAb(+)rates(40.0% VS 19.4%,P=0.009)and FT3 levels(2.81±0.45pg/m L VS 2.57±0.63 pg/m L,P=0.026)were higher in the CIDP group(n=35)than in the control group(n=160).2.In the GBS/CIDP group,cranial nerve involvement(42.3% VS 18.2%,P < 0.05),autonomic nerve dysfunction(53.8% VS 27.3%,)and autonomic nerve dysfunction(53.8% vs 27.3%,)were significantly higher than those in the TMAb/TGAb(+)group(n=26)and TMAb/TGAb(-)group(n=55).P=0.021),the history of prodrome infection(40.9% VS 16.0%,P=0.022)was significantly higher.In the GBS group,the TMAb/TGAb(+)group(n=12)and TMAb/TGAb(-)group(n=34)had dyspnea(50.0% VS 8.8%,P=0.002),preinfection(75.0% VS 23.5%,P=0.001)and cranial nerve involvement(58.3% VS 20.6%,P=0.015)were significantly increased.In CIDP group,the rate of autonomic dysfunction was significantly higher in TMAb/TGAb(+)group(n=14)and TMAb/TGAb(-)group(n=21)(63.3% VS 9.5%,P=0.001).3.GBS/CIDP group,GBS and CIDP group,TMAb(+)/TGAb(-)group,there was no statistical difference in demyelination,axonal injury,coexisting of both,motor nerve involvement,sensory nerve involvement and nerve root involvement.4.In GBS/CIDP group,the positive rate of TMAb/TGAb was positively correlated with cranial nerve involvement(R=0.257,P=0.022)and autonomic nerve dysfunction(R=0.259,P=0.021).In GBS group,the positive rate of TMAb/TGAb was positively correlated with cranial nerve involvement(R=0.360,P=0.016)and dyspnea(R=0.456,P=0.002).In CIDP group,the positive rate of TMAb/TGAb was negatively correlated with HFGS score at admission(R=-0.330,P=0.036),and positively correlated with autonomic cranial nerve dysfunction(R=0.578,P=0.001).Conclusion:1.Patients with Guillain-Barre syndrome often have positive thyroid antibody,which is correlated with thyroid antibody(TMAb/TGAb).2.Patients with GBS/CIDP combined with TMAb/TGAb(+)had more symptoms and more severe disease than those with TMAb/TGAb(-),but there was no difference in electromyography,cerebrospinal fluid and prognosis.3.Thyroid antibody TMAb/TGAb may be used as one of the markers to assess the severity of Guillain-Barre syndrome. |
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