Effect Of Hyperglycemia And Hyperlipidemia On PSA Levels In Patients With Prostate Cancer And Prostatic Hyperplasia

Objective(s):To investigate the serum prostate-specific antigen(PSA)for prostate cancer and prostatic hyperplasia,By exploring the correlation between hyperglycemia,hyperlipemia and PSA,Make clinicians fully consider that abnormal blood glucose and lipid levels may cause abnormal expression of serum PSA levels,In order to evaluate metabolic abnormalities as a related factor affecting serum PSA levels,Better application of PSA to prostate cancer(PCa)screening,benign prostatic hyperplasia(BPH),And the evaluation of prostate cancer treatment,follow-up,and prognosis.Methods: Systematic review of patients with prostate cancer and prostate hyperplasia in December 2018-2022,analyzed the case information meeting the inclusion criteria,applied statistical methods including group comparison,covariance analysis and spearman grade correlation analysis,analyzed the data analysis software SPSS 26.0 to clarify the correlation between hyperglycemia and hyperlipidemia and serum PSA expression level in patients with prostate cancer and prostate hyperplasia.Results: 1.A total of 626 patients with type 2 diabetes(T2DM),age,prostate volume(PV),Body Mass Index(BMI),fasting blood glucose,and lipid levels,serum PSA,pathological results,and clinical stage of prostate cancer were collected.Among them,211 patients were included in the type 2 diabetes group,140 patients were included in the hyperlipidemia group,and 275 patients were included without metabolic diseases.2.After different group stratification between T2 DM group and no metabolic disease group,the serum PSA,f PSA and PV of PCa and BPH patients in(1)T2DM group decreased compared with NT2 DM control group;(2)stratified the T2 DM group according to whether the use of hypoglycemic drugs,the serum PSA and f PSA of PCa and BPH patients decreased more significantly than those in the group without hypoglycemic drugs.(3)In T2 DM group,the proportion of T4 patients in PCa patients was lower compared with NT2 DM group,and there was no significant difference in pathological Gleason score and the proportion of clinical stages of T1,T2 and T3.3.In the comparison between hyperlipidemic group and control patients without metabolic abnormalities:(1)Hyperlipidemic patients had higher BMI,while age,serum PSA,f PSA,f / t PSA and PV were not significantly different between the two groups.(2)The proportion of Gleason 7 and T2 and T4 in the hyperlipidemia PCa group was less than that in the control group.4.After studying the correlation between age,PV,BMI,and fasting blood glucose and serum PSA,it was found that in(1)age in patients had no metabolic abnormalities;PV in T2 DM,hyperlipidemia and no metabolic abnormalities,and BMI,cholesterol,triglycerides and LDL and serum PSA levels in all group.(2)Fasting blood glucose level was positively correlated with PSA in the T2 DM,T2DM PCa,T2 DM BPH and NT2 DM BPH groups.However,after grouping according to the hypoglycemic group,fasting blood glucose was positively correlated with serum PSA and f PSA only in the T2 DM PCa and BPH groups,and no significant correlation was found in the untreated group.5.After correcting for the effect of age and PV on serum PSA level: the serum PSA level of PCa and BPH patients in the(1)T2DM,T2 DM PCa,T2 DM BPH,T2 DM group with antidiabetic drugs were significantly lower than those in the control group,and the serum PSA level in PCa group with 5 years was more significant than that in the group with <5years.(2)Although the serum PSA levels of PCa and BPH patients in the T2 DM group were lower compared with the control group,the difference was not significant.Conclusion(s): 1.Type 2 diabetes mellitus leads to lower serum PSA levels in patients with prostate cancer and benign prostatic hyperplasia.It may be related to the duration of diabetes mellitus and the use of antidiabetic drugs.2.If the increase of fasting blood glucose level after the use of hypoglycemic drugs may decrease the decrease of serum PSA level in diabetic patients.3 Prostate volume was positively correlated with serum PSA level.4 There had no significant effect on serum PSA expression.