Short-term Clinical Efficacy Of Methylene Blue Photodynamic Therapy In The Treatment Of Erosive Oral Lichen Planus

Objective:By observing the short-term clinical efficacy of Methylene blue-Photodynamic Therapy(MB-PDT)in the treatment of Oral lichen planus(OLP),the effectiveness,safety and influencing factors of Methylene blue-Photodynamic Therapy in the treatment of Oral lichen planus were investigated in order to provide reference and basis for the promotion and application of this therapy in clinical practice.Methods:The 106 patients with vesicular oral lichen planus were randomly divided into three groups by drawing ping-pong balls,in which 37 patients in the kangfuxin Liquid group were treated with conventional drugs,34 patients in the photodynamic group were treated with methylene blue photodynamic therapy on the basis of the control group,and 35 patients in the hormone group were treated with topical application of trimethoprim econazole cream on the basis of the control group.The detailed clinical data of the patients were collected,and the size of intraoral erosion area,VAS pain score,changes in sign notation score,adverse reactions and recurrence rate of the three groups were observed and recorded before and after 4 weeks of treatment,and the efficacy of the three groups was evaluated with reference to the clinical efficacy evaluation criteria of erosive oral lichen planus.Results:1.The hormone group and photodynamic group were better than the kangfuxin Liquid group in terms of reduction of lesion area,reduction of VAS pain score and reduction of sign score,and the difference was statistically significant(P<0.05);the hormone group was better than the photodynamic group in terms of reduction of lesion area and reduction of sign score,and the difference was statistically significant(P<0.05),but the difference between the photodynamic group and the hormone group in terms of reduction of VAS pain score was not statistically significant(P>0.05).2.The effective rates of the kangfuxin Liquid group,photodynamic group and hormone group were45.9%,85.3%and 91.5%,respectively,and the effective rates of the photodynamic group and hormone group were significantly better than those of the kangfuxin Liquid group with statistically significant differences(p<0.05);the difference between the effective rates of the photodynamic group and hormone group was not statistically significant(p>0.05).3.Methylene blue photodynamic therapy had better efficacy on celiac OLP with lesion area less than 2cm~2,disease duration less than 6 months and non-smoking,and the difference was statistically significant(p<0.05).4.The incidence of adverse reactions in the kangfuxin Liquid group,photodynamic group and hormone group were 0%,2.9%and 5.7%,respectively,and the difference between the three groups was not statistically significant(p>0.05).5.The recurrence rates in the two groups within six months were 6.8%and 12.5%,respectively,and the differences between the two groups were not statistically significant(P>0.05).Conclusions:methylene blue photodynamic therapy for the treatment of erosive oral lichen planus has similar efficacy to the topical use of hormones,with lower adverse effects and recurrence rates,and it is expected to become an alternative or complementary therapy to the first-line use of corticosteroids.