Analysis Of Clinical Differences And Risk Factors Of Neo-natal Streptococcus Agalactiae Infection And Planting

Objective: To explore the clinical characteristics of neonatal Streptococcus agalactiae infection and planting,and to analyze the clinical differences and risk factors,in order to provide reference for early identification and treatment of Streptococcus agalactiae infection.Method: 1.Newborns who were born and hospitalized in the Affiliated Hospital of Guilin Medical College from July 2019 to December 2022 and tested positive for GBS by real-time fluorescence quantitative PCR of nasopharyngeal swabs were selected as subjects and divided into planting group and infection group according to the entry standards.2.The clinical data of the subjects were collected,including general data,maternal data,clinical manifestations and signs,neonatal outcomes,umbilical cord blood and venous blood cell count,placental pathological tissue and imaging examination.3.The data were analyzed by SPSS 25.0.Result: 1.A total of 118 cases of GBS positive newborn were included in the PCR method,60 cases of planting groups,and 58 infected groups.2.There were no statistically significant differences in preterm birth,low birth weight,mother GBS positive,mother GDM,and fetal membrane breakfast between infection group and planting group(P>0.05).3.Multivariate Logistic regression analysis shows that the fever during mothers(OR=4.490,95%CI:1.090-18.498,P<0.05),chorionic shenatitis(OR=3.214,95%CI:1.048-9.857,P<0.05),and amniotic fluid pollution(OR=21.685,95%CI:2.6799-175.559,P<0.05)were independent risk factors for neonatal Streptococcus agalactiae infection.4.Infection group umbilical white blood cell count and neutral granulocyte counting level is higher than the planting group,the difference is statistically significant(P<0.05);There was no statistically significant difference in hemoglobin,platelet count and I/T between the infection group and the planting group(P>0.05).5.Infection group umbilical leukocyte counting,neutral granulocyte counting is lower than venous blood,the difference is statistically significant(P<0.05);There was no statistically significant difference in white blood cell count and neutrophil count between umbilical cord blood and venous blood in the planting group(P>0.05);6.There was statistical significance in CRP between infection group and planting group(P<0.05).The area under the receiver operating characteristic curve of CRP was 0.601,and the optimal critical value was 0.53 mg/L,with a sensitivity of 53.4% and a specificity of 68.3%.Conclusion:1.Maternal fever,amniotic fluid contamination,chorioamnionitis were independent risk factors of Streptococcus agalactiae infection in neonates.2.For newborns with positive GBS screening in throat swabs,the increase of white blood cell count and neutrophil count in umbilical cord blood suggests an increased risk of GBS infection.3.For neonates with positive GBS screening in throat swabs,the white blood cell count and neutrophil count in venous blood within 24 hours of admission were higher than those in umbilical cord blood,suggesting an increased risk of GBS infection.4.The predictive diagnostic value of CRP in neonatal GBS infection is low.It is necessary to seek indicators for combined diagnosis to avoid missed diagnosis.