Dynamic Changes Of NLR,PLR And MPV In Blood Routine Cell During Perioperative Period In Patients With Ⅰ-Ⅲ Non-small Cell Lung Cancer

Objective: To investigate the dynamic changes of cellular components NLR,PLR and platelet morphology MPV in patients with stage I-III nonsmall cell lung cancer(NSCLC)during perioperative blood routine.Methods:(1)258 patients with non-small cell lung cancer(NSCLC)who were hospitalized in the Department of Thoracic and Cardiovascular Operation of the First Affiliated Hospital of Hebei North University from January 2019 to September 2022 and underwent radical resection of lung cancer were selected.All patients were confirmed by postoperative histopathology,and none of them received chemotherapy and radiotherapy before operation.(2)Information of patients’ gender,smoking history,underlying diseases,operative modalities,pathological type,pathological stage,and lymph node metastasis were collected.Fasting peripheral venous blood was drawn within 1 week before operation(T0),on postoperative day1(T1),on postoperative day 5(T2),on postoperative day 7(T3),and on postoperative month 1(T4)and sent to the clinical laboratory for blood routine examination,recording the neutrophil,lymphocyte and platelet.NLR,PLR and MPV at the corresponding five time points were calculated and these parameters were clinically analyzed by dynamic changes.Statistical analysis was performed by SPSS 25.0 to compare differences between groups.Results: 1.The NLR level increased to the peak value on the first day after operation and the PLR level increased to the peak value on the fifth day after operation,which were significantly higher than preoperative level and then gradually decreased.The NLR and PLR level on the seventh day and one month after operation were significantly higher than the NLR and PLR baseline value within one week before operation(P < 0.05).The MPV level continued to decrease after operation and the MPV level on the fifth day,the seventh day and one month after operation was significantly lower than the MPV baseline value within one week before operation(P < 0.05).2.The NLR and PLR level within one week before operation,on the seventh day and one month after operation in the stage III group were significantly higher than those in the stage I group(P<0.05),the MPV level within one week before operation,on the first day,the fifth day,the seventh day and one month after operation in the stage III group were significantly lower than those in the stage I groups(P<0.05).The NLR,PLR and MPV in stage I patients basically recovered to preoperative level one week after operation and maintain close to preoperative level one month after operation while in stage II patients basically recovered to preoperative level one month after operation.The NLR and PLR level in stage III patients were still significantly higher than the preoperative level one month after operation(P<0.05)while the MPV level was still significantly lower than the preoperative level one month after operation(P<0.05).3.The NLR level in patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis while the MPV level was significant lower on the seventh day and one month after operation(P<0.05).The NLR and PLR in patients without lymph node metastasis were still significantly higher than the preoperative level while the MPV was lower at one week after operation and recovered to preoperative level one month after operation.The NLR and PLR in patients with lymph node metastasis remained significantly higher than preoperative level one month after operation(P<0.05)while the MPV level remained significantly lower(P<0.05).Conclusion: 1.Perioperative blood routine of NLR,PLR in patients with I-III non-small cell lung cancer will rise first and then fall while MPV will fall first and then rise,which lasting up to one month after operation.2.Patients with later TNM stage or lymph node metastasis have higher levels of NLR and PLR and lower levels of MPV at the seventh day and one month after operation,and slower recovery.3.The trend of perioperative blood routine NLR and MPV in patients with stage Ⅰ-Ⅲ non-small cell lung cancer is of guiding significance for evaluating the presence of lymph node matastasis.