Relationship Between NLR,PLR,SIRI And Atherosclerotic Cerebral Infarction

Objective:To explore the correlation between NLR,PLR,SIRI and the occurrence of atherosclerotic cerebral infarction and the severity of lesions.Methods:A retrospective collection of 185 patients who were hospitalized for Digital subtraction angiography(DSA)in the Department of Neurology of the Second Hospital of Shanxi Medical University from January 2021 to August 2022 and diagnosed with ACI was included as the study group,and 732 healthy physical examiners during the same period were included as the control group.Using Propensity Score Matching,the tendencies scores of the enrolled participants were calculated and matched 1:1,and finally the study group(178 cases)and the control group(178 cases)were established.The patients’ basic data were collected to calculate NLR,PLR,SIRI.In addition,according to the results of DSA,the study group was divided into mild to moderate stenosis group(45cases),severe stenosis group(133 cases),single lesion group(92 cases),multi-branch lesion group(86 cases),limited lesion group(35 cases),and diffuse lesion group(143cases).The independent sample t-test and the Mann-Whitney U test were used to analyze continuous variables between groups,and the chi-square test was used to compare the differences in categorical variables,and the independent protection or risk factors for ACI were determined by multivariate logistic regression analysis.Pearson correlation analysis was used to evaluate the correlation between novel inflammatory indexes and NIHSS scores.Multivariate logistic regression analysis was used to evaluate whether each novel inflammatory index was an independent risk factor for cerebral artery severity,and the ROC curve was used to evaluate the predictive value of each novel inflammatory index on cerebral artery severity.Results:1.Increases in NLR(OR=1.330,P=0.001),PLR(OR=1.007,P=0.002),and SIRI(OR=1.259,P=0.047)were risk factors for the development of ACI;2.SIRI(r=0.533,P<0.001)was positively correlated with NIHSS scores;3.Elevated NLR(OR=1.807,P=0.004),PLR(OR=1.010,P=0.009),and SIRI(OR=5.525,P=0.001)were risk factors for severe stenosis of cerebral arteries;NLR(OR=1.710,P=0.001),PLR(OR=1.008,P=0.008),SIRI(OR=2.650,P=0.001)were risk factors for polyvessel lesions of cerebral arteries;NLR(OR=1.078,P=0.572),PLR(OR=1.000,P=0.877),SIRI(OR=0.775,P=0.339)were not influencing factors of diffuse lesions of cerebral arteries.4.SIRI has a good predictive value for severe narrow and multivessel lesions of cerebral arteries,and the optimal threshold for predicting severe stenosis of cerebral arteries is 0.895(sensitivity 84.1%,specificity 43.5%),and the optimal threshold for predicting polyvessel lesions of cerebral arteries is 1.16(sensitivity 76.7%,specificity41.3%).Conclusions:1.Increased levels of NLR,PLR,and SIRI are correlated with the occurrence of ACI;the level of SIRI can reflect to some extent the severity of neurological impairment;2.Elevated levels of NLR,PLR,and SIRI were associated with severe stenosis and multivessel lesions of cerebral arteries,and SIRI had a good predictive value for severe stenosis and multivessel lesions of cerebral arteries.