Effect Of Ciprofol On Cerebral Oxygen Saturation During Induction Of General Anesthesia In Diabetes Patients With Microangiopathy

Objective:To investigate the differences in the effects on basal vital signs,cerebral oxygen saturation,and short-term postoperative cognitive function when ciprofol and propofol are used for surgical general anesthesia induction in diabetic patients to predict their effects on perioperative cerebral perfusion;To evaluate the safety of ciprofol when used for general anesthesia induction,thereby providing theoretical support for its use in the clinic.Methods:Sixty patients with type II diabetes who underwent surgery under general anesthesia between October 2021 and October 2022 were selected and divided into propofol and ciprofol groups（30 each）by random digit method.After induction with“propofol+sufentanil+CIS atracurium”and“ciprofol+sufentanil+CIS atracurium”regimens,respectively,were used to compare the mean arterial pressure（MAP）,heart rate（HR）,local cerebral oxygen saturation（r Sc O₂）,and brain electrical bispectral index（BIS）values between the two groups at enter into the operating room（T₀）,after induction of intubation（T₁）,30min after induction of intubation（T₂）,and the end of surgery（T₃）;Venous blood was collected from patients at T₁to measure lactate（Lac）and serum C-reactive protein（CRP）levels;At the same time,the mini mental state examination（MMSE）was administered to assess the cognitive function of the patients 1d before,1d after,and 7d after surgery.Results:when comparing the clinical data between the two groups in the propofol and ciprofol groups,there was an interaction between the time points of map and the groups（P<0.05）.For further analysis of the separate effects,there was no significant difference in the main effect between the groups（P>0.05）,the difference in the main effect between the time points was statistically significant（P<0.05）,and the map level immediately after induction in the ciprofol group decreased less than that in the propofol group before surgery.There was no significant difference in the main effect between time points for HR,r Sc O₂,and BIS（P<0.05）or between groups（P>0.05）,and there was no interaction between time points and groups（P>0.05）,indicating that there is no significant difference in the effects of propofol on HR,r Sc O₂,and BIS when propofol is used for anesthesia induction.The levels of Lac and CRP before and after induction in the test group were also not significantly different from those in the control group（P>0.05）.There was no significant difference in the main effects of time point,between groups on MMSE scores（P>0.05）,and there was no interaction between time point and group（P>0.05）.Similarly,compared preoperatively,cognitive function was slightly reduced 1d postoperatively in both propofol and ciprofol groups,with no significant difference between the two groups.The incidences of total adverse events in the ciprofol and propofol groups were33.33%（10/30）and 70%（21/30）,respectively,with significant differences between the two groups（P<0.05）.Conclusion:when used for surgical general anesthesia induction in patients with diabetes,ciprofol significantly reduces postinduction hypotension and the incidence of intraoperative related adverse events compared with propofol;In terms of the effect on the body’s perioperative cerebral oxygen saturation and the improvement of postoperative short-term cognitive function,the two basically do not differ.