A Study Of Vitamin D And Platelet Parameters In Community-acquired Pneumonia In Children

Objective:To assess the predictive value of serum vitamin D levels and platelet parameters on the severity of community-acquired pneumonia（CAP）in children and to investigate whether platelet parameters correlate with serum vitamin D levels in CAP in children.Methods:We retrospectively analyzed the case data of 110 children admitted to the department of pediatrics of the First Hospital of Shanxi Medical University with CAP and divided the children into mild（n=68）and severe（n=42）groups according to the severity of their conditions.The gender,age,body mass index（BMI）,serum 25-（OH）D₃ concentration,platelet counts（PLT）,mean platelet volume（MPV）,platelet distribution width（PDW）,platelet-to-lymphocyte ratio（PLR）,and systemic immune-inflammation index（SII）was calculated,to compare the differences between the two groups of laboratory indicators.ROC curves were used to analyze the potential value of serum vitamin D levels and platelet parameters to predict the severity of CAP in children and to calculate the correlation between platelet parameters and vitamin D.Results:1.When comparing the laboratory indices between the two groups,serum 25-（OH）D₃concentration and PLT were higher in the mild group than in the severe group（P<0.05）,while MPV,PLR,and SII were lower than in the severe group（P<0.05）,but PDW was not significant between the two groups（P>0.05）.2.ROC analysis of serum 25-（OH）D₃ concentration,PLT,MPV,PLR,and SII to assess the severity of CAP in children suggested that the area under the ROC curve of serum 25-（OH）D₃ concentration,PLT,MPV,PLR,and SII were 0.676,0.667,0.693,0.700,and 0.853,respectively,with SII having the highest diagnostic efficacy.The sensitivity and specificity were 64.3%,69.1%,42.9%,89.7%,64.3%,67.6,59.5%,83.8%,76.2%,89.7%at the critical values of 64.04nmo/L,166.50×10^9/L,9.65f L,103.69,647.87,respectively.3.PLT was positively correlated with serum 25-（OH）D₃ concentration（r_s=0.465,P<0.05）,MPV was negatively correlated with serum 25-（OH）D₃ concentration（r_s=-0.568,P<0.05）,PDW,PLR,and SII were not correlated with serum 25-（OH）D₃ concentration（P>0.05）.Conclusions:Decreased serum 25-（OH）D₃concentration and PLT value and increased MPV,PLR,and SII indicators in children with CAP may suggest the possibility of severe CAP,and there is a correlation between platelet count and volume and serum vitamin D levels in children with CAP.