| At present,cancer is still one of the most serious diseases that endanger human life and health in the world.The traditional treatment methods of cancer mainly include surgical treatment,radiotherapy and drug chemotherapy,but these treatment methods have certain limitations.Surgical treatment often leads to recurrence or metastasis due to incomplete tumor resection,while radiotherapy and drug chemotherapy have obvious side effects and are more harmful to the human body.Compared with traditional cancer treatment methods,phototherapy has higher inherent specificity and lower invasion burden,and has high efficiency,short cycle and obvious effect,so it has attracted widespread attention.Phototherapy includes photothermal therapy and photodynamic therapy.Single-mode phototherapy often has many shortcomings.For example,photothermal therapy is often due to the uneven distribution of photothermal agents,and the remaining tumor cells quickly produce heat resistance,resulting in low efficiency of photothermal therapy.In addition,photodynamic therapy is affected by the hypoxic microenvironment of the tumor site,and it is difficult to fully kill tumor cells.At present,synergistic phototherapy generally uses two different wavelengths of laser irradiation to produce photothermal and photodynamic therapy effects,or uses multiple components to form a photosensitizer for synergistic phototherapy,which not only affects the efficiency of phototherapy but also increases the difficulty of treatment.Therefore,we designed a single molecule heptamethyl cyanine derivative nanotherapeutic agent for tumor synergistic phototherapy.This nanotheranostic system has the following characteristics :(1)Nanodisk structure formed by supramolecular assembly;(2)Aggregation and retention at the tumor site through the EPR effect;(3)Single-molecule photosensitizer can simultaneously produce photothermal and photodynamic therapeutic effects under single-band laser irradiation;(4)The synergistic phototherapy of nanoparticles can successfully eliminate tumors and has good biosafety. |
