Analysis Of Correlation Between Osteopontin And LUTS Symptoms In Patients With Benign Prostatic Hyperplasia

Objective This project mainly studies the expression difference of Osteopontin(OPN)in patients with inflammatory and non-inflammatory Prostatic Hyperplasia(BPH),and explores the mechanism of OPN in the process of fibrosis and inflammation of BPH.To analyze the correlation between OPN and male lower urinary tract symptoms(LUTS),understand the role of OPN in the onset and clinical progression of BPH,and provide theoretical basis for early active intervention,delay or even control of LUTS,so as to improve the quality of life of patients.Reduce the occurrence of complications.Methods This study is a retrospective study.The subjects were enrolled in the Department of Urology,Baotou Central Hospital from May 2021 to December 2022.They complained of progressive dysuria and were diagnosed as BPH after detailed preoperative medical history,physical examination and auxiliary examination.transurethral resection of the prostate(TURP)was performed in 120 patients who were eligible for surgical indications.Prostate resection was diagnosed and grouped by pathologists of our hospital using international classification of prostatitis histology.There were 76 cases of prostatic hyperplasia with inflammation(inflammatory group)and 44 cases of pure prostatic hyperplasia(non-inflammatory group).Serum osteopontin content in patients with prostatic hyperplasia was determined by enzyme linked immunosorbent assay(Elisa).Osteopontin expression in prostate tissues of the enrolled patients was determined by immunohistochemistry(IHC)and differences in protein expression during pure prostatic hyperplasia and prostatic hyperplasia with inflammation were analyzed.Statistical software(SPSS26.0)was used to analyze the experimental data.The measurement data were expressed as mean±standard deviation.After normality test and homogeneity test of variance,T/Z test was applied to the two groups of data.Binary Logistic regression analysis(multivariate)and Receiver operating characteristic curve(ROC)analysis were used for statistical analysis.Two-sided test was used for statistical analysis results,and the significance test level was set at α=0.05.Reaults This study results show that the hyperplasia of prostate inflammation group of osteopontin in the blood levels than simply a group of patients with hyperplasia of prostate,P=0.013,statistically significant difference(P<0.05).In terms of the expression of immunohistochemical marker OPN in the hyperplasia tissues of prostate,the expression of OPN in the hyperplasia inflammatory group and the non-inflammatory group was different(P=0.037),and the difference was statistically significant(P<0.05).Inflammation group and non-inflammatory IPSS,SSS,VSS,QOL score significantly different,inflammation group had a significantly higher scores than inflammation group,with significant difference(P<0.001).The comparison of the maximum flow rate(Qmax)between the inflammatory group and the non-inflammatory group showed that the maximum flow rate was significantly different between the two groups,and the maximum flow rate in the non-inflammatory group was significantly higher than that in the inflammatory group,with statistically significant difference(P<0.001).Blood OPN was positively correlated with IPSS score(P=0.013),that is,it was positively correlated with lower urinary tract symptoms,and the difference was statistically significant(P<0.05).In the postoperative follow-up,IPSS scores of both groups were decreased and Qmax was increased compared with those before surgery.The symptoms of lower urinary tract in the non-inflammatory group were improved more significantly than those before surgery.The area under ROC curve(AUC=0.751,95%CI=0.656-0.846)of OPN for predicting prostatic hyperplasia with inflammation was 23.43,the sensitivity and specificity were 63.64% and 76.32%,respectively.The Yoden index is 0.399.The binary Logistic regression analysis showed that OPN content can be used as a predictor of hyperplasia of prostate with inflammation(OR=1.128,P=0.012).Conclusion This topic analyzed the relationship between osteopontin and inflammation,analyzed the relationship between inflammation and lower urinary tract symptoms,and further explored the relationship between osteopontin and lower urinary tract symptoms.This study found that there were differences in the content of OPN in blood and the expression in tissues between patients with prostatic hyperplasia accompanied by inflammation and simple prostatic hyperplasia,and the content of OPN in blood and the expression in tissues of patients with prostatic hyperplasia accompanied by inflammation were higher than those of patients with simple prostatic hyperplasia.The IPSS,SSS,VSS and QOL scores of the inflammatory group and the non-inflammatory group were significantly different,and the scores of the inflammatory group were significantly higher than those of the non-inflammatory group.There were differences in Qmax between the inflammatory group and the non-inflammatory group,and the non-inflammatory group had significantly higher Qmax than the inflammatory group.Lower urinary tract symptoms were significantly different between the inflammatory and non-inflammatory groups,and LUTS with prostate hyperplasia and inflammation were more severe.Blood OPN content was positively correlated with lower urinary tract symptoms.In the postoperative follow-up,IPSS scores of both groups were decreased and Qmax was increased compared with those before surgery.The symptoms of lower urinary tract in the non-inflammatory group were improved more significantly than those before surgery.OPN has an important predictive value for whether patients with prostatic hyperplasia are accompanied by inflammation,and provides a theoretical basis for early anti-inflammatory therapy,delay or even control of LUTS,so as to improve patients’ quality of life.