Expression Level And Clinical Significance Of IL-17 And IL-33 In Infants With Asthmatic Pneumonia

Objective:The purpose of this study was to investigate the role and clinical significance of IL-17 and IL-33 in infants with asthmatic pneumonia by detecting the expression levels of IL-17 and IL-33 in plasma,as well as the levels of exhaled nitric oxide(Fe NO)and lung function,and to analyze the correlation.To provide feasible detection indicators for the early identification and disease assessment of infant asthmatic pneumonia,and to analyze the characteristics of disease etiology,so as to provide certain basis for clinical diagnosis and treatment.Methods:Eighty cases of infant asthmatic pneumonia hospitalized in the pediatric ward of Inner Mongolia Autonomous Region People’s Hospital from October 2021 to September 2022 were selected as the case group and 80 healthy children who underwent physical examination in the pediatric outpatient department during the same period were selected as the control group.Oral and pharyngeal swabs were collected for pathogen detection in the case group upon admission;venous blood,Fe NO and lung function levels were collected and recorded in the acute stage and convalesce stage,respectively;venous blood was collected during physical examination in the control group.Plasma levels of IL-17 and IL-33 were detected by enzyme-linked immunosorbent assay(ELISA),and their correlation with Fe NO and lung function and etiological characteristics were analyzed.Meanwhile,clinical characteristics and laboratory indicators of the children in the case group were collected for statistical analysis.Results:1.The expression levels of IL-17 and IL-33 in acute stage and convalescence stage were significantly higher in case group than in control group.The expression levels of IL-17 and IL-33 in acute stage were significantly higher than those in convalescent stage,and the differences were statistically significant(P<0.05).2.Fe NO level in the acute stage was significantly higher than that in the convalesce stage,and lung function VT,TPTEF/TE and VPEF/VE levels in the convalesce stage were significantly higher than that in the acute stage,with statistical significance.3.The levels of IL-17 and IL-33 in the acute stage were positively correlated with Fe NO levels(IL-17:r=0.766,P<0.05;IL-33:r=0.734,P<0.05),were negatively correlated with VT,TPTEF/TE and VPEF/VE(IL-17:r=-0.666、-0.695、-0.789,P<0.05;IL-33:r=-0.712、-0.779、-0.807,P<0.05).4.According to ROC curve analysis,the AUC values of IL-17 and IL-33 in the case group were 0.985 and 0.945,respectively,which had certain predictive value for infant asthmatic pneumonia.logistic regression analysis showed that IL-33 may be an independent risk factor for infant asthmatic pneumonia.5.In the case group,the pathogen detection rate was 87.5%,of which the single pathogen detection rate was 68.75%,and the mixed pathogen detection rate was18.75%.The detection rate of single pathogen from high to low was: respiratory syncytial virus(33.75%,27 cases),rhinovirus(20%,16 cases),adenovirus(6.25%,5cases),parainfluenza virus(6.25%,5 cases).Conclusion:1.IL-17 and IL-33 are highly expressed in infants with asthmatic pneumonia,which may affect Fe NO and lung function by aggravating airway inflammation and injury,play a pro-inflammatory role in the pathogenesis of infants with asthmatic pneumonia,and can be used as an early predictor of infants with asthmatic pneumonia.2.IL-33 may be an independent risk factor for infant asthmatic pneumonia.3.Respiratory syncytial virus(RSV)is the most common pathogen in infant asthmatic pneumonia.